Holm G
Acta Med Scand Suppl. 1979;628:85-8. doi: 10.1111/j.0954-6820.1979.tb00788.x.
The immunological side-effects under treatment with antihypertensive drugs are mainly limited to autoimmunity and autoimmune disease caused by alpha-methyldopa and hydralazine. Autoimmune hemolytic anemia is more common during treatment with alpha-methyldopa. Hydralazine may induce antinuclear antibodies. Some patients develop a SLE-like syndrome. Its clinical picture is less severe and its prognosis is more favourable than that of spontaneous SLE. During treatment with low doses the disease develops exclusively in patients who are slow acetylators. It may appear also in rapid acetylators during the high dose treatment. The symptoms are usually reversible after withdrawal of the drug.
抗高血压药物治疗的免疫副作用主要局限于由甲基多巴和肼屈嗪引起的自身免疫及自身免疫性疾病。自身免疫性溶血性贫血在甲基多巴治疗期间更为常见。肼屈嗪可诱导抗核抗体产生。一些患者会出现类系统性红斑狼疮综合征。其临床表现较自发性系统性红斑狼疮轻，预后也更好。小剂量治疗时，该病仅在慢乙酰化者中发生。大剂量治疗时，快乙酰化者也可能出现。停药后症状通常可逆转。
