贾第虫病中免疫反应、微生物群与发病机制的交叉
The Intersection of Immune Responses, Microbiota, and Pathogenesis in Giardiasis.
作者信息
Fink Marc Y, Singer Steven M
机构信息
Department of Biology, Georgetown University, Washington, DC, USA.
Department of Biology, Georgetown University, Washington, DC, USA.
出版信息
Trends Parasitol. 2017 Nov;33(11):901-913. doi: 10.1016/j.pt.2017.08.001. Epub 2017 Aug 19.
Abstract
Giardia lamblia is one of the most common infectious protozoans in the world. Giardia rarely causes severe life-threatening diarrhea, and may even have a slight protective effect in this regard, but it is a major contributor to malnutrition and growth faltering in children in the developing world. Giardia infection also appears to be a significant risk factor for postinfectious irritable bowel and chronic fatigue syndromes. In this review we highlight recent work focused on the impact of giardiasis and the mechanisms that contribute to the various outcomes of this infection, including changes in the composition of the microbiota, activation of immune responses, and immunopathology.
摘要
蓝氏贾第鞭毛虫是世界上最常见的传染性原生动物之一。蓝氏贾第鞭毛虫很少引起严重的、危及生命的腹泻，甚至在这方面可能有轻微的保护作用，但它是发展中国家儿童营养不良和生长发育迟缓的主要原因。蓝氏贾第鞭毛虫感染似乎也是感染后肠易激综合征和慢性疲劳综合征的一个重要危险因素。在这篇综述中，我们重点介绍了最近的研究工作，这些工作聚焦于贾第虫病的影响以及导致这种感染各种后果的机制，包括微生物群组成的变化、免疫反应的激活和免疫病理学。
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