School of Kinesiology, Shanghai University of Sport, 399 Chang Hai Road, Shanghai, 200438, P.R. China.
School of Kinesiology, Shanghai University of Sport, 399 Chang Hai Road, Shanghai, 200438, P.R. China.
Ageing Res Rev. 2017 Nov;40:45-50. doi: 10.1016/j.arr.2017.08.004. Epub 2017 Aug 19.
Aging is an important contributor to olfactory system deterioration in humans, leading to increased health and safety risks as well as affecting the quality of life. However, it is currently unknown when age-related olfactory deterioration begins in humans and thus when to initiate interventions to prevent or slow it.
To determine the decade in which olfactory function begins to deteriorate in healthy humans by determining when odor identification is first impaired.
Studies cited in the PubMed database were searched from its inception to March 2017 using the terms "olfac*" or "smell" and "ag*". The effect size of each comparison was calculated.
In this meta-analysis, the effect sizes as determined using Cohen's d for the comparisons between 30 and 39.9- and 40-49.9-year-olds was 0.06 (95% CI: -0.17 to 0.29), between 40-49.9-year-olds was 0.62 (95% CI: 0.20-1.04), considered a medium effect size, and between 35-55-year-olds and those >55years old was 1.12 (95% CI: 1.06-1.45), considered a very large effect.
Olfactory function deterioration, as determined by an impaired ability to identify odors, starts in the fifth decade of life in healthy humans.
衰老对人类嗅觉系统的退化有重要影响，这增加了健康和安全风险，也影响了生活质量。然而，目前尚不清楚人类的嗅觉衰退从何时开始，因此也无法确定何时开始进行干预以预防或减缓这种衰退。
通过确定嗅觉识别能力首次受损的时间，确定健康人类的嗅觉功能开始恶化的十年。
从 PubMed 数据库建立到 2017 年 3 月，使用术语“olfac*”或“smell”和“ag*”搜索数据库中引用的研究。计算每个比较的效应量。
在这项荟萃分析中，使用 Cohen's d 计算 30-39.9 岁和 40-49.9 岁之间以及 40-49.9 岁和 35-55 岁之间以及 55 岁以上之间的比较的效应大小分别为 0.06（95% CI：-0.17 至 0.29）、0.62（95% CI：0.20 至 1.04）和 1.12（95% CI：1.06 至 1.45），分别被认为是中等和非常大的效应。
健康人群中，嗅觉功能的退化（通过嗅觉识别能力受损来确定）始于第五个十年。
