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1
TSH and PRL, side-effect markers in aripiprazole treatment: adjunctive aripiprazole-induced thyrotropin oversuppression in a young man with schizophrenia.促甲状腺激素和催乳素，阿立哌唑治疗中的副作用标志物：一名患有精神分裂症的年轻男性中阿立哌唑辅助治疗引起的促甲状腺素过度抑制
BMJ Case Rep. 2017 Aug 22;2017:bcr-2017-220192. doi: 10.1136/bcr-2017-220192.
2
[Frequency of increased thyrotropin in women with hyperprolactinemia].[高催乳素血症女性促甲状腺激素升高的频率]
Rev Med Inst Mex Seguro Soc. 2017;55 Suppl 1:S53-S57.
3
Serum thyrotropin and prolactin in the syndrome of generalized resistance to thyroid hormone: responses to thyrotropin-releasing hormone stimulation and short term triiodothyronine suppression.全身性甲状腺激素抵抗综合征中的血清促甲状腺激素和催乳素：对促甲状腺激素释放激素刺激和短期三碘甲状腺原氨酸抑制的反应
J Clin Endocrinol Metab. 1990 May;70(5):1305-11. doi: 10.1210/jcem-70-5-1305.
4
Prolactin and TSH response to TRH and metoclopramide before and after l-thyroxine therapy in subclinical hypothyroidism.亚临床甲状腺功能减退症患者在左甲状腺素治疗前后，催乳素和促甲状腺激素对促甲状腺激素释放激素和甲氧氯普胺的反应。
Neuroendocrinology. 1986;43(6):676-8. doi: 10.1159/000124603.
5
Effect of an oral water load on serum TSH in normal subjects, and on TSH and prolactin response to thyrotropin-releasing hormone (TRH) in patients with primary hypothyroidism.口服水负荷对正常受试者血清促甲状腺激素（TSH）的影响，以及对原发性甲状腺功能减退症患者TSH和催乳素对促甲状腺激素释放激素（TRH）反应的影响。
J Clin Endocrinol Metab. 1975 Oct;41(4):784-7. doi: 10.1210/jcem-41-4-784.
6
The physiological role of thyrotropin-releasing hormone in the regulation of thyroid-stimulating hormone and prolactin secretion in the rat.促甲状腺激素释放激素在调节大鼠促甲状腺激素和催乳素分泌中的生理作用。
J Clin Invest. 1978 Feb;61(2):441-8. doi: 10.1172/JCI108955.
7
[Aripiprazole induced Parkinsonism: A case report].[阿立哌唑诱发的帕金森症：一例报告]
Encephale. 2009 Oct;35(5):496-8. doi: 10.1016/j.encep.2008.06.019. Epub 2009 Jan 8.
8
Lack of effect of the TRH related dipeptide histidyl-proline diketopiperazine on TSH and PRL secretion in normal subjects, in patients with microprolactinomas and in primary hypothyroidism.TRH相关二肽组氨酰-脯氨酸二酮哌嗪对正常受试者、微泌乳素瘤患者及原发性甲状腺功能减退患者促甲状腺激素和泌乳素分泌无影响。
Clin Endocrinol (Oxf). 1985 Sep;23(3):289-93. doi: 10.1111/j.1365-2265.1985.tb00226.x.
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[Hyperthyroidism and subjects hyperresponding to thyrotropin. Importance of simultaneous thyrotropin and prolactin determination following administration of thyroid-releasing hormone].[甲状腺功能亢进症与促甲状腺激素反应过度的受试者。给予促甲状腺激素释放激素后同时测定促甲状腺激素和催乳素的重要性]
Sem Hop. 1980;56(17-18):827-31.
10
Plasma thyrotropin-releasing hormone, prolactin, thyrotropin, and thyroxine concentrations following the intravenous or oral administration of thyrotropin-releasing hormone.静脉注射或口服促甲状腺激素释放激素后血浆促甲状腺激素释放激素、催乳素、促甲状腺激素和甲状腺素的浓度
Am J Obstet Gynecol. 1979 Nov 15;135(6):737-42. doi: 10.1016/0002-9378(79)90384-3.

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Non-linear relationship between TSH and psychotic symptoms on first episode and drug naïve major depressive disorder patients: a large sample sized cross-sectional study in China.中国一项大样本量横断面研究：首发未用药的单相重性抑郁障碍患者 TSH 与精神病性症状的非线性关系。
BMC Psychiatry. 2024 Jun 4;24(1):413. doi: 10.1186/s12888-024-05860-7.
2
Redefining the Cut-Off Ranges for TSH Based on the Clinical Picture, Results of Neuroimaging and Laboratory Tests in Unsupervised Cluster Analysis as Individualized Diagnosis of Early Schizophrenia.基于临床症状、神经影像学结果及实验室检查，通过无监督聚类分析重新定义促甲状腺激素的临界值范围，以实现早期精神分裂症的个体化诊断。
J Pers Med. 2022 Feb 9;12(2):247. doi: 10.3390/jpm12020247.
3
Abnormally low prolactin levels in schizophrenia patients after switching to aripiprazole in a randomized trial: a biomarker for rebound in psychotic symptoms?在一项随机试验中，精神分裂症患者换用阿立哌唑后催乳素水平异常降低：精神病症状反弹的生物标志物？
BMC Psychiatry. 2020 Nov 23;20(1):552. doi: 10.1186/s12888-020-02957-7.

本文引用的文献

1
Dopamine D2 receptor expression in the corticotroph cells of the human normal pituitary gland.多巴胺D2受体在人正常垂体促肾上腺皮质激素细胞中的表达。
Endocrine. 2017 Aug;57(2):314-325. doi: 10.1007/s12020-016-1107-2. Epub 2016 Oct 13.
2
Aripiprazole-Associated Hypoprolactinemia in the Clinical Setting.临床环境中与阿立哌唑相关的低催乳素血症
J Clin Psychopharmacol. 2016 Aug;36(4):385-7. doi: 10.1097/JCP.0000000000000527.
3
Aripiprazole-Induced Hypoprolactinemia in an Adult Male with First-Episode Psychosis.阿立哌唑致首发精神病成年男性低催乳素血症
Clin Schizophr Relat Psychoses. 2016 Winter;9(4):173-6. doi: 10.3371/CSRP.PRJA.022015. Epub 2015 Feb 24.
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Review: Combination therapy with non-clozapine atypical antipsychotic medication: a review of current evidence.综述：非氯氮平非典型抗精神病药物联合治疗：当前证据综述。
J Psychopharmacol. 2007 Aug;21(6):657-64. doi: 10.1177/0269881106071334. Epub 2006 Nov 8.
5
Mesolimbic dopamine D3 receptors and use of antipsychotics in patients with schizophrenia. A postmortem study.中脑边缘多巴胺D3受体与精神分裂症患者抗精神病药物的使用。一项尸检研究。
Arch Gen Psychiatry. 1997 Mar;54(3):225-32. doi: 10.1001/archpsyc.1997.01830150047009.
6
Synthetic thyrotropin-releasing hormone. A potent stimulator of thyrotropin secretion in man.合成促甲状腺激素释放激素。人体促甲状腺激素分泌的强效刺激剂。
N Engl J Med. 1971 Dec 2;285(23):1279-83. doi: 10.1056/NEJM197112022852302.
7
Further evidence that TRH is also a physiological regulator of PRL secretion in man.进一步的证据表明，促甲状腺激素释放激素也是人类催乳素分泌的生理调节因子。
Biochem Biophys Res Commun. 1973 Apr 2;51(3):512-21. doi: 10.1016/0006-291x(73)91344-2.
8
Dopamine stimulates release of thyrotrophin-releasing hormone from perfused intact rat hypothalamus via hypothalamic D2-receptors.多巴胺通过下丘脑D2受体刺激灌注完整大鼠下丘脑释放促甲状腺激素释放激素。
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促甲状腺激素和催乳素，阿立哌唑治疗中的副作用标志物：一名患有精神分裂症的年轻男性中阿立哌唑辅助治疗引起的促甲状腺素过度抑制

TSH and PRL, side-effect markers in aripiprazole treatment: adjunctive aripiprazole-induced thyrotropin oversuppression in a young man with schizophrenia.

作者信息

Ohta Hidenobu, Inoue Satoru, Hara Koichiro, Watanabe Akihiko

机构信息

Department of Psychophysiology, National Institute of Mental health, National Center of Neurology and Psychiatry, Kodaira, Japan.

Department of Psychiatry, Asai Hospital, Togane, Japan.

出版信息

BMJ Case Rep. 2017 Aug 22;2017:bcr-2017-220192. doi: 10.1136/bcr-2017-220192.

DOI:10.1136/bcr-2017-220192
PMID:28830897
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5614012/
Abstract

A 26-year-old Japanese man was admitted to our unit with exacerbated paranoid schizophrenia. Prior to his admission, daily administration of olanzapine had been sufficient to maintain a partial remission of his schizophrenia, but due to an exacerbation of his delusions, he had then also been prescribed aripiprazole, which had been followed by no improvement in symptoms and a gradual further exacerbation of auditory delusions. Physical examinations, brain MRI and neurophysiological assessment were unremarkable. Blood analysis, however, revealed extremely low thyroid-stimulating hormone (TSH) and prolactin-releasing hormone (PRL) concentration. Interestingly, after aripiprazole discontinuation, he returned to partial remission with an increase in plasma TSH and PRL concentration.

摘要

一名26岁的日本男性因偏执型精神分裂症加重入住我院。入院前，每日服用奥氮平足以维持其精神分裂症的部分缓解，但由于妄想症状加重，他随后还被开了阿立哌唑，但症状并未改善，幻听妄想逐渐进一步加重。体格检查、脑部MRI和神经生理学评估均无异常。然而，血液分析显示促甲状腺激素（TSH）和催乳素释放激素（PRL）浓度极低。有趣的是，停用阿立哌唑后，他恢复到部分缓解状态，血浆TSH和PRL浓度升高。