State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Chaoyang, Beijing, China.
University of the Chinese Academy of Sciences, Beijing, China.
Sci Rep. 2017 Aug 22;7(1):9144. doi: 10.1038/s41598-017-08287-1.
We used county level data for T2D prevalence across the mainland USA and matched this to county level ambient PM2.5. Multiple linear regression was used to determine the relation between prevalence of T2D with PM2.5 after adjustment for confounding factors. PM2.5 explained 6.3% of the spatial variation in obesity, and 17.9% of the spatial variation in T2D. After correcting the T2D prevalence for obesity, race, poverty, education and temperature, PM2.5 still explained 8.3% of the residual variation in males (P < 0.0001) and 11.5% in females (P < 0.0001). The effect on obesity prevalence corrected for poverty, race education and temperature was much lower and hence the ratio of T2D to obesity prevalence was significantly associated with PM2.5 in males (R = 11.1%, P < 0.0001) and females (R = 16.8%, P < 0.0001). This association was repeated across non-African countries (R = 14.9%, P < 0.0001). High levels of PM2.5 probably contribute to increased T2D prevalence in the USA, but have a more minor effect on the obesity. Exposure to high environmental levels of PM2.5 (relative to the USA) may explain the disproportional risk of T2D in relation to obesity in Asian populations.
我们使用了美国大陆的县级 T2D 患病率数据，并将其与县级环境 PM2.5 进行了匹配。采用多元线性回归方法，在调整混杂因素后，确定了 T2D 患病率与 PM2.5 之间的关系。PM2.5 解释了肥胖的空间变异的 6.3%，以及 T2D 的空间变异的 17.9%。在对肥胖、种族、贫困、教育和温度校正后，PM2.5 仍然解释了男性 T2D 患病率的 8.3%（P < 0.0001）和女性的 11.5%（P < 0.0001）。经过校正后的肥胖率、贫困率、种族、教育和温度的 PM2.5 对 T2D 患病率的影响要低得多，因此 T2D 与肥胖患病率的比值与 PM2.5 之间存在显著相关性，男性（R = 11.1%，P < 0.0001）和女性（R = 16.8%，P < 0.0001）。这种相关性在非非洲国家也得到了重复（R = 14.9%，P < 0.0001）。美国 PM2.5 水平较高可能导致 T2D 患病率上升，但对肥胖的影响较小。暴露于高环境水平的 PM2.5（相对于美国）可能解释了亚洲人群中 T2D 与肥胖相关的不成比例的风险。
