Laboratory of Molecular Genetics, National Centre for Laboratory Animal Sciences, National Institute of Nutrition, Hyderabad, 500 007, Telangana, India.
Sci Rep. 2017 Aug 22;7(1):9162. doi: 10.1038/s41598-017-09149-6.
Obesity, a multifactorial disorder, results from a chronic imbalance of energy intake vs. expenditure. Apart from excessive consumption of high calorie diet, genetic predisposition also seems to be equally important for the development of obesity. However, the role of genetic predisposition in the etiology of obesity has not been clearly delineated. The present study addresses this problem by selecting three rat strains (WNIN, F-344, SD) with different genetic backgrounds and exposing them to high calorie diets. Rat strains were fed HF, HS, and HFS diets and assessed for physical, metabolic, biochemical, inflammatory responses, and mRNA expression. Under these conditions: significant increase in body weight, visceral adiposity, oxidative stress and systemic pro-inflammatory status; the hallmarks of central obesity were noticed only in WNIN. Further, they developed altered glucose and lipid homeostasis by exhibiting insulin resistance, impaired glucose tolerance, dyslipidemia and fatty liver condition. The present study demonstrates that WNIN is more prone to develop obesity and associated co-morbidities under high calorie environment. It thus underlines the cumulative role of genetics (nature) and diet (nurture) towards the development of obesity, which is critical for understanding this epidemic and devising new strategies to control and manage this modern malady.
肥胖是一种多因素疾病，源于能量摄入与消耗之间的慢性失衡。除了过量摄入高热量饮食外，遗传易感性似乎对肥胖的发生也同样重要。然而，遗传易感性在肥胖发病机制中的作用尚未明确界定。本研究通过选择三种遗传背景不同的大鼠品系（WNIN、F-344、SD）并将其暴露于高热量饮食中，来解决这一问题。大鼠品系分别给予 HF、HS 和 HFS 饮食，并评估其生理、代谢、生化、炎症反应和 mRNA 表达。在这些条件下：体重、内脏脂肪、氧化应激和全身促炎状态显著增加；仅在 WNIN 中观察到中心性肥胖的特征。此外，它们通过表现出胰岛素抵抗、葡萄糖耐量受损、血脂异常和脂肪肝状态，导致葡萄糖和脂质稳态发生改变。本研究表明，在高热量环境下，WNIN 更容易发生肥胖及相关合并症。这突出了遗传（本质）和饮食（教养）在肥胖发展中的累积作用，这对于理解这一流行疾病以及制定控制和管理这种现代疾病的新策略至关重要。
