Moorthy Mohanambal, Wie Chong Chun, Mariño Eliana, Palanisamy Uma D
Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway 47500, Selangor, Malaysia.
School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway 47500, Selangor, Malaysia.
Antioxidants (Basel). 2022 Mar 25;11(4):632. doi: 10.3390/antiox11040632.
Geraniin, an ellagitannin, has ameliorative properties against high-fat diet (HFD)-induced metabolic syndrome. Since geraniin has poor bioavailability, we hypothesised the interaction of this compound with gut microbiota as the main mechanism for improving metabolic aberrations. Male Sprague Dawley rats were divided into normal diet (ND)- and HFD-fed animals and treated with geraniin and an enriched extract of geraniin (GEE). We observed that 5 mg geraniin and 115 mg GEE supplementation significantly attenuated glucose intolerance, lipopolysaccharide-binding protein, total cholesterol, triacylglyceride, and low-density lipoprotein; improved insulin sensitivity; and significantly increased adiponectin and hepatic PPARα expression. Although geraniin and GEE did not significantly alter the gut microbial composition, we found an increment in the relative abundance of a few butyrate producers such as , , , and . Geraniin and its enriched extract's ability to ameliorate metabolic syndrome parameters while positively affecting the growth of butyrate-producing bacteria suggests its potential prebiotic role.
老鹳草素，一种鞣花单宁，对高脂饮食（HFD）诱导的代谢综合征具有改善作用。由于老鹳草素的生物利用度较差，我们推测该化合物与肠道微生物群的相互作用是改善代谢异常的主要机制。将雄性Sprague Dawley大鼠分为正常饮食（ND）组和高脂饮食组，并分别用老鹳草素和老鹳草素富集提取物（GEE）进行处理。我们观察到，补充5毫克老鹳草素和115毫克GEE可显著减轻葡萄糖不耐受、脂多糖结合蛋白、总胆固醇、三酰甘油和低密度脂蛋白水平；提高胰岛素敏感性；并显著增加脂联素和肝脏PPARα的表达。虽然老鹳草素和GEE没有显著改变肠道微生物组成，但我们发现一些丁酸盐产生菌如[此处原文缺失具体菌名]、[此处原文缺失具体菌名]、[此处原文缺失具体菌名]和[此处原文缺失具体菌名]的相对丰度有所增加。老鹳草素及其富集提取物改善代谢综合征参数的能力，同时对丁酸盐产生菌的生长产生积极影响，表明其具有潜在的益生元作用。
