患有囊性纤维化患儿的父母的精神挣扎增加了患抑郁症的几率。

Spiritual Struggle in Parents of Children with Cystic Fibrosis Increases Odds of Depression.

作者信息

Szczesniak Rhonda D, Zou Yuanshu, Stamper Sophia M, Grossoehme Daniel H

机构信息

Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

出版信息

Depress Res Treat. 2017;2017:5670651. doi: 10.1155/2017/5670651. Epub 2017 Jul 31.

DOI:10.1155/2017/5670651

PMID:28831310

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5555001/

Abstract

OBJECTIVE

Spiritual struggle (SS) is associated with poorer health outcomes including depression. The study's main objectives were to characterize change in depression over time, examine longitudinal associations between SS and depression, and determine the extent to which experiencing SS at baseline was predictive of developing depression at follow-up.

METHODS

A two-site study collected questionnaire responses of parents ( = 112; 72% female) of children with cystic fibrosis followed longitudinally. Generalized linear mixed effects modeling examined the association between depression and SS over time and assessed potential mediators, moderators, and confounders.

RESULTS

Prevalence of depression increased from baseline to follow-up (OR: 3.6, < 0.0001), regardless of degree of SS. Parents with Moderate/Severe SS were more likely to have depressive symptoms, compared to parents without SS (OR: 15.2, = 0.0003) and parents who had Mild SS (OR: 10.2, = 0.0001). Being female and feeling less "at peace" also significantly predicted increased depression (OR: 2.5, = 0.0397, and OR: 1.15, = 0.0419, resp.). Experiencing SS at baseline was not predictive of having depression subsequently at follow-up.

CONCLUSIONS

Parents experiencing SS were significantly more likely to report depressive symptoms. Interventions to reduce SS have shown efficacy and may be considered.

摘要

目的

精神挣扎（SS）与包括抑郁症在内的较差健康结果相关。该研究的主要目的是描述抑郁症随时间的变化特征，研究SS与抑郁症之间的纵向关联，并确定基线时经历SS在多大程度上可预测随访时患抑郁症的情况。

方法

一项双地点研究纵向收集了患有囊性纤维化儿童的父母（n = 112；72%为女性）的问卷调查回复。广义线性混合效应模型研究了抑郁症与SS随时间的关联，并评估了潜在的中介因素、调节因素和混杂因素。

结果

无论SS程度如何，抑郁症患病率从基线到随访均有所增加（OR：3.6，P < 0.0001）。与无SS的父母（OR：15.2，P = 0.0003）和患有轻度SS的父母（OR：10.2，P = 0.0001）相比，患有中度/重度SS的父母更有可能出现抑郁症状。女性以及感觉“内心不平静”也显著预测了抑郁症的增加（分别为OR：2.5，P = 0.0397，以及OR：1.15，P = 0.0419）。基线时经历SS并不能预测随访时随后患抑郁症的情况。