Hypertension in Africa Research Team (HART), North-West University (Potchefstroom Campus), Private Bag X6001, Potchefstroom, 2520, South Africa.
MRC Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa.
Amino Acids. 2017 Nov;49(11):1843-1853. doi: 10.1007/s00726-017-2483-5. Epub 2017 Aug 22.
The relationship of both asymmetric (ADMA) and symmetric (SDMA) dimethylarginine with carotid wall thickness is inconclusive especially among black populations. We aimed to compare carotid intima media thickness (cIMT) and dimethylarginine levels in 75 black and 91 white men at baseline and after a 3-year follow-up, and to investigate associations of percentage change in cIMT with percentage change in dimethylarginine levels (ADMA and SDMA). Plasma levels of ADMA and SDMA were determined with a liquid chromatography mass spectrometry method and B-mode ultrasonography was used to determine the cIMT at baseline and follow-up. In black men, mean cIMT (p = 0.79) and ADMA levels (p = 0.67) remained the same, but SDMA levels were lower (p < 0.001) when comparing baseline and follow-up. In white men, cIMT increased (p < 0.001), but both mean ADMA and SDMA levels decreased (p < 0.001) over time. In black men, percentage change in cIMT was positively associated with percentage change in ADMA (R = 0.49; β = 0.46; p < 0.001) and percentage change in SDMA (R = 0.46; β = 0.41; p < 0.001). These associations were absent in the white men. Despite lower mean SDMA and similar ADMA and cIMT in black men, percentage change in cIMT was independently associated with percentage change in ADMA and percentage change in SDMA. These results suggest an important role for ADMA and SDMA lowering strategies to delay carotid wall thickening, especially in black populations prone to the development of cardiovascular disease.
不对称二甲基精氨酸（ADMA）和对称二甲基精氨酸（SDMA）与颈动脉壁厚度的关系尚无定论，尤其是在黑人人群中。我们旨在比较 75 名黑人男性和 91 名白人男性在基线时和 3 年后的颈动脉内膜中层厚度（cIMT）和二甲基精氨酸水平，并探讨 cIMT 的百分比变化与二甲基精氨酸水平（ADMA 和 SDMA）的百分比变化之间的关系。采用液相色谱-质谱法测定 ADMA 和 SDMA 的血浆水平，采用 B 型超声检查在基线和随访时测定 cIMT。在黑人男性中，cIMT（p=0.79）和 ADMA 水平（p=0.67）保持不变，但 SDMA 水平在基线和随访时较低（p<0.001）。在白人男性中，cIMT 增加（p<0.001），但 ADMA 和 SDMA 水平随时间均降低（p<0.001）。在黑人男性中，cIMT 的百分比变化与 ADMA（R=0.49；β=0.46；p<0.001）和 SDMA（R=0.46；β=0.41；p<0.001）的百分比变化呈正相关。这些关联在白人男性中不存在。尽管黑人男性的平均 SDMA 水平较低，ADMA 和 cIMT 相似，但 cIMT 的百分比变化与 ADMA 和 SDMA 的百分比变化独立相关。这些结果表明，降低 ADMA 和 SDMA 的策略对于延缓颈动脉壁增厚具有重要作用，尤其是在易发生心血管疾病的黑人人群中。
