Hypertension in Africa Research Team (HART), Faculty of Health Sciences, North-West University, Private Bag X1290, Potchefstroom, 2520, South Africa.
MRC Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa.
Amino Acids. 2020 Jul;52(6-7):965-973. doi: 10.1007/s00726-020-02866-9. Epub 2020 Jun 29.
The L-arginine derivatives asymmetric (ADMA) and symmetric dimethylarginine (SDMA), as well as L-homoarginine may have opposing effects in the pathogenesis of atherosclerosis. We aimed to investigate (i) 5-year changes in arginine derivatives, and (ii) the association between baseline arginine derivatives and follow-up measures of carotid wall thickness in South Africans.
This study included men (n = 187) and women (n = 396) who took part in the 2010 and 2015 data collections of the South African arm of the Prospective Urban and Rural Epidemiology (PURE) study. Arginine derivatives were determined in plasma with liquid chromatography-tandem mass spectrometry. Carotid intima-media thickness (cIMT) and cross-sectional wall area (CSWA) were determined with B-mode ultrasonography.
Mean values of arginine derivatives did not change over time. In the study group, follow-up cIMT (β = - 0.10 p = 0.018) and CSWA (β = - 0.12; p = 0.004) inversely associated with baseline L-homoarginine, and cIMT inversely associated with ADMA (β = - 0.09; p = 0.033). In women, CSWA inversely associated with both ADMA (β = - 0.11; p = 0.034) and L-homoarginine (β = - 0.11; p = 0.024). No such associations were found in men.
These results suggest that higher levels of L-homoarginine may play a protective role against vascular injury and delay progression of carotid wall thickening in this cohort. The role of ADMA in atherosclerosis deserves further investigation in this population.
精氨酸衍生物不对称（ADMA）和对称二甲基精氨酸（SDMA）以及 L-高半胱氨酸在动脉粥样硬化的发病机制中可能具有相反的作用。我们旨在研究：（i）精氨酸衍生物的 5 年变化；（ii）基线精氨酸衍生物与南非人群颈动脉壁厚度随访测量值之间的关联。
本研究纳入了参加前瞻性城市和农村流行病学（PURE）研究南非部分 2010 年和 2015 年数据收集的男性（n=187）和女性（n=396）。使用液相色谱-串联质谱法测定血浆中的精氨酸衍生物。通过 B 型超声测量颈动脉内膜中层厚度（cIMT）和横截面积（CSWA）。
精氨酸衍生物的平均值在随访期间没有变化。在研究组中，随访 cIMT（β= - 0.10，p= 0.018）和 CSWA（β= - 0.12；p= 0.004）与基线 L-高半胱氨酸呈负相关，cIMT 与 ADMA 呈负相关（β= - 0.09；p= 0.033）。在女性中，CSWA 与 ADMA（β= - 0.11；p= 0.034）和 L-高半胱氨酸（β= - 0.11；p= 0.024）均呈负相关。在男性中未发现这种关联。
这些结果表明，较高水平的 L-高半胱氨酸可能在该队列中发挥保护作用，防止血管损伤并延缓颈动脉壁增厚的进展。ADMA 在动脉粥样硬化中的作用值得在该人群中进一步研究。
