肝脏侵袭性血管黏液瘤：一例报告及文献复习
Aggressive angiomyxoma of the liver: a case report and literature review.
作者信息
Sato Koki, Ohira Masahiro, Shimizu Seiichi, Kuroda Shintarou, Ide Kentaro, Ishiyama Kohei, Kobayashi Tsuyoshi, Tahara Hiroyuki, Shiroma Noriyuki, Arihiro Koji, Imamura Michio, Chayama Kazuaki, Ohdan Hideki
机构信息
Department of Gastroenterological and Transplant Surgery, Applied Life Sciences, Institute of Biomedical & Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Department of Pathology, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
出版信息
Surg Case Rep. 2017 Aug 23;3(1):92. doi: 10.1186/s40792-017-0365-4.
BACKGROUND
Aggressive angiomyxoma (AAM) is a rare mesenchymal tumor that occurs almost exclusively in the soft tissue of the pelvis and perineum. AAM has both locally infiltrative and recurrent characteristics. Very few cases of AAM occurring outside of the pelvis and perineum have been reported. Here, we report a case of AAM originating in the liver of a 33-year-old female patient.
CASE PRESENTATION
A 33-year-old woman underwent S8 subsegmentectomy after clinical diagnosis of a mucinous cystic neoplasm of the liver. Histological analysis revealed a tumor composed of spindle-shaped cells with vascular proliferation in a myxoid stroma. Immunohistochemically, the tumor cells stained positively for CD34, estrogen receptor (ER), and progesterone receptor (PgR) and negatively for S-100, EMA, CK19, CD99, HMB45, and α-smooth muscle actin. The tumor was diagnosed as AAM originating from the liver. The patient received no adjuvant chemotherapy. No sign of recurrence or distant metastasis has been noted for 10 months after the surgery.
CONCLUSIONS
We here report a second case of AAM originating from the liver, which is an uncommon location for this particular tumor.
背景
侵袭性血管黏液瘤（AAM）是一种罕见的间叶性肿瘤，几乎仅发生于盆腔和会阴的软组织。AAM具有局部浸润和复发的特点。仅有极少数AAM发生于盆腔和会阴以外部位的病例报道。在此，我们报告一例起源于一名33岁女性患者肝脏的AAM病例。
病例介绍
一名33岁女性在临床诊断为肝脏黏液性囊性肿瘤后接受了S8亚段切除术。组织学分析显示肿瘤由梭形细胞组成，在黏液样基质中有血管增生。免疫组化结果显示，肿瘤细胞CD34、雌激素受体（ER）和孕激素受体（PgR）呈阳性，而S-100、EMA、CK19、CD99、HMB45和α-平滑肌肌动蛋白呈阴性。该肿瘤被诊断为起源于肝脏的AAM。患者未接受辅助化疗。术后10个月未发现复发或远处转移迹象。
结论
我们在此报告第二例起源于肝脏的AAM病例，该部位对于这种特殊肿瘤而言并不常见。
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