光动力疗法：现状与未来方向。
Photodynamic therapy: current status and future directions.
作者信息
Benov Ludmil
机构信息
Department of Biochemistry, Faculty of Medicine, Health Sciences Centre, Kuwait University, Jabriya, Kuwait.
出版信息
Med Princ Pract. 2015;24 Suppl 1(Suppl 1):14-28. doi: 10.1159/000362416. Epub 2014 May 10.
Abstract
Photodynamic therapy (PDT) is a minimally invasive therapeutic modality used for the management of a variety of cancers and benign diseases. The destruction of unwanted cells and tissues in PDT is achieved by the use of visible or near-infrared radiation to activate a light-absorbing compound (a photosensitizer, PS), which, in the presence of molecular oxygen, leads to the production of singlet oxygen and other reactive oxygen species. These cytotoxic species damage and kill target cells. The development of new PSs with properties optimized for PDT applications is crucial for the improvement of the therapeutic outcome. This review outlines the principles of PDT and discusses the relationship between the structure and physicochemical properties of a PS, its cellular uptake and subcellular localization, and its effect on PDT outcome and efficacy.
摘要
光动力疗法（PDT）是一种用于治疗多种癌症和良性疾病的微创治疗方式。在光动力疗法中，通过使用可见光或近红外辐射来激活一种光吸收化合物（一种光敏剂，PS），从而实现对不需要的细胞和组织的破坏。在分子氧存在的情况下，这种光敏剂会产生单线态氧和其他活性氧物质。这些细胞毒性物质会损伤并杀死靶细胞。开发具有针对光动力疗法应用进行优化特性的新型光敏剂对于改善治疗效果至关重要。本综述概述了光动力疗法的原理，并讨论了光敏剂的结构与物理化学性质、其细胞摄取和亚细胞定位之间的关系，以及其对光动力疗法结果和疗效的影响。
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