Widmann R, Mensdorff-Pouilly N, Pfaller K, Sperk G
J Neurochem. 1987 Jun;48(6):1857-61. doi: 10.1111/j.1471-4159.1987.tb05748.x.
The origin of afferent somatostatin-containing fibers terminating in medial and ventral parts of the striatum has been investigated by performing various neurochemical and surgical lesions in the rat. Lesions of the anterior hypothalamus, amygdala, and the hippocampal commissure as well as lesions with 6-hydroxydopamine and 5,7-dihydroxytryptamine failed to decrease striatal somatostatin levels. However, thermal coagulation of the globus pallidus or knife-cut lesions performed ventrally to the striatum resulted in significant decreases in striatal somatostatin content. Analysis of the topographical distribution of somatostatin within the striatum after thermal lesions of the globus pallidus as well as after kainic acid-induced seizures revealed a preferential loss of the peptide in medial and ventral portions of the striatum, the site of terminating afferent somatostatin nerve fibers. The data suggest that the striatal afferent somatostatin-containing neurons may originate in the area of the globus pallidus.
通过对大鼠进行各种神经化学和手术损伤，研究了终止于纹状体内侧和腹侧部分的含生长抑素传入纤维的起源。下丘脑前部、杏仁核和海马连合的损伤以及用6-羟基多巴胺和5,7-二羟基色胺造成的损伤均未能降低纹状体生长抑素水平。然而，苍白球热凝或在纹状体腹侧进行的刀切损伤导致纹状体生长抑素含量显著降低。对苍白球热损伤后以及红藻氨酸诱发癫痫后纹状体内生长抑素的地形分布分析显示，纹状体的内侧和腹侧部分（即含生长抑素传入神经纤维的终末部位）的该肽优先丢失。数据表明，纹状体含生长抑素的传入神经元可能起源于苍白球区域。
