Beal M F, Domesick V B, Martin J B
Brain Res. 1985 Mar 25;330(2):309-16. doi: 10.1016/0006-8993(85)90690-0.
Somatostatin has been found in substantial amounts in the basal ganglia by radioimmunoassay and has been demonstrated in both neurons and nerve terminals. Since the levels of somatostatin have been shown to vary in Huntington's and Alzheimer's disease it was of interest to see whether such changes could be produced experimentally. Lesions of the periventricular nucleus of the hypothalamus and knife cuts adjacent to this nucleus had no effect on striatal somatostatin-like immunoreactivity (SLI). Similarly lesions of medio-dorsal frontal cortex, and those isolating pyriform cortex or the olfactory bulb had no effect on striatal SLI. Removal of the amygdala resulted in significant increases in SLI in the ipsilateral striatum and nucleus accumbens, suggesting loss of an inhibitory interaction. Stria terminalis lesions failed to reproduce this effect suggesting that it is mediated via amygdalo-striatal projections traveling in the dorsal longitudinal bundle. Other findings support a somatostatin projection to the amygdala from the bed nucleus of the stria terminalis and one from the amygdala to the ventromedial hypothalamus.
通过放射免疫测定法已发现基底神经节中存在大量生长抑素，并且在神经元和神经末梢中均有显示。由于已表明生长抑素水平在亨廷顿病和阿尔茨海默病中有所变化，因此有必要了解此类变化是否可通过实验产生。下丘脑室周核损伤以及该核附近的刀切伤对纹状体生长抑素样免疫反应性（SLI）没有影响。同样，中背额叶皮质损伤以及隔离梨状皮质或嗅球的损伤对纹状体SLI也没有影响。杏仁核切除导致同侧纹状体和伏隔核中SLI显著增加，表明抑制性相互作用丧失。终纹床核损伤未能重现此效应，提示其通过在背侧纵束中走行的杏仁核 - 纹状体投射介导。其他研究结果支持从终纹床核到杏仁核以及从杏仁核到腹内侧下丘脑的生长抑素投射。
