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人乳腺癌细胞系T47D中雌性甾体激素对人内源性逆转录病毒基因组表达的刺激作用

Stimulation of expression of the human endogenous retrovirus genome by female steroid hormones in human breast cancer cell line T47D.

作者信息

Ono M, Kawakami M, Ushikubo H

出版信息

J Virol. 1987 Jun;61(6):2059-62. doi: 10.1128/JVI.61.6.2059-2062.1987.

DOI:10.1128/JVI.61.6.2059-2062.1987
PMID:2883329
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC254220/
Abstract

Expression of the human endogenous retrovirus genome HERV-K, homologous to mouse mammary tumor virus, was investigated in cultured human tumor cells. In several cell lines, the HERV-K genome was expressed as an 8.8-kilobase poly(A)+ RNA which appeared to be a full-size transcript of this genome. In the human breast cancer cell line T47D, stimulation of HERV-K genome expression by progesterone was observed after estradiol treatment.

摘要

在培养的人类肿瘤细胞中，研究了与小鼠乳腺肿瘤病毒同源的人类内源性逆转录病毒基因组HERV-K的表达情况。在几种细胞系中，HERV-K基因组表达为一种8.8千碱基的聚腺苷酸化RNA，它似乎是该基因组的全长转录本。在人类乳腺癌细胞系T47D中，经雌二醇处理后，观察到孕酮对HERV-K基因组表达的刺激作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66d4/254220/b0c14e7aaea2/jvirol00097-0305-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66d4/254220/c0d74b214269/jvirol00097-0304-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66d4/254220/b0c14e7aaea2/jvirol00097-0305-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66d4/254220/c0d74b214269/jvirol00097-0304-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66d4/254220/b0c14e7aaea2/jvirol00097-0305-a.jpg

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1
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Virology. 1984 Oct 30;138(2):225-35. doi: 10.1016/0042-6822(84)90347-7.
2
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Proc Natl Acad Sci U S A. 1984 Jul;81(13):4188-92. doi: 10.1073/pnas.81.13.4188.
3
The human genome contains multiple sequences of varying homology to mouse mammary tumour virus DNA.
肿瘤中 HERV 激活的机制调控及其对肿瘤学转化研究的意义。
Front Cell Infect Microbiol. 2024 Feb 6;14:1358470. doi: 10.3389/fcimb.2024.1358470. eCollection 2024.
4
Human Endogenous Retrovirus-K (HML-2)-Related Genetic Variation: Human Genome Diversity and Disease.人类内源性逆转录病毒-K（HML-2）相关遗传变异：人类基因组多样性与疾病。
Genes (Basel). 2023 Nov 28;14(12):2150. doi: 10.3390/genes14122150.
5
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6
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Viruses. 2023 Mar 9;15(3):710. doi: 10.3390/v15030710.
8
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10
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4
Regulation of mouse mammary tumor virus gene expression by glucocorticoid hormones.糖皮质激素对小鼠乳腺肿瘤病毒基因表达的调控
Curr Top Microbiol Immunol. 1983;106:79-103. doi: 10.1007/978-3-642-69357-1_4.
5
The glucocorticoid receptor binds to defined nucleotide sequences near the promoter of mouse mammary tumour virus.糖皮质激素受体与小鼠乳腺肿瘤病毒启动子附近特定的核苷酸序列结合。
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6
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7
Retrovirus-related sequences in human DNA: detection and cloning of sequences which hybridize with the long terminal repeat of baboon endogenous virus.人类DNA中与逆转录病毒相关的序列：与狒狒内源性病毒长末端重复序列杂交的序列的检测与克隆。
Nucleic Acids Res. 1982 May 11;10(9):2865-78. doi: 10.1093/nar/10.9.2865.
8
Sequence organization of cloned intracisternal A particle genes.克隆的脑内A粒子基因的序列组织
Cell. 1980 Sep;21(2):465-73. doi: 10.1016/0092-8674(80)90483-3.
9
DNA sequences bound specifically by glucocorticoid receptor in vitro render a heterologous promoter hormone responsive in vivo.在体外与糖皮质激素受体特异性结合的DNA序列，在体内可使异源启动子对激素产生反应。
Cell. 1983 Jun;33(2):489-99. doi: 10.1016/0092-8674(83)90430-0.
10
Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.变性RNA与转移至硝酸纤维素膜上的小DNA片段的杂交。
Proc Natl Acad Sci U S A. 1980 Sep;77(9):5201-5. doi: 10.1073/pnas.77.9.5201.