人乳腺癌细胞系T47D中雌性甾体激素对人内源性逆转录病毒基因组表达的刺激作用
Stimulation of expression of the human endogenous retrovirus genome by female steroid hormones in human breast cancer cell line T47D.
作者信息
Ono M, Kawakami M, Ushikubo H
出版信息
J Virol. 1987 Jun;61(6):2059-62. doi: 10.1128/JVI.61.6.2059-2062.1987.
Abstract
Expression of the human endogenous retrovirus genome HERV-K, homologous to mouse mammary tumor virus, was investigated in cultured human tumor cells. In several cell lines, the HERV-K genome was expressed as an 8.8-kilobase poly(A)+ RNA which appeared to be a full-size transcript of this genome. In the human breast cancer cell line T47D, stimulation of HERV-K genome expression by progesterone was observed after estradiol treatment.
摘要
在培养的人类肿瘤细胞中，研究了与小鼠乳腺肿瘤病毒同源的人类内源性逆转录病毒基因组HERV-K的表达情况。在几种细胞系中，HERV-K基因组表达为一种8.8千碱基的聚腺苷酸化RNA，它似乎是该基因组的全长转录本。在人类乳腺癌细胞系T47D中，经雌二醇处理后，观察到孕酮对HERV-K基因组表达的刺激作用。
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