Noda M, Kurihara M, Takano T
Nucleic Acids Res. 1982 May 11;10(9):2865-78. doi: 10.1093/nar/10.9.2865.
Human DNA sequences which hybridized with the long terminal repeats (LTR) of baboon type C virus M7 were detected by non-stringent blot hybridization. About 7 to 10 discrete bands of the LTR-related sequences were commonly observed in the DNAs from four independent human cell lines after digestion with either Eco RI, Hind III or Bam HI. The amounts of these sequences were more abundant in tumor cell lines than in a non-malignant cell line. The human sequences related to the M7 LTR seemed to be located at relatively specific sites on the cell DNA. The human DNA clones which hybridized with M7 LTR were detected in the human DNA library described by Lawn et al. (Cell 15, 1157-1174, 1978), at a frequency of about 300 per haploid genome. Five clones were isolated which shared different extent of homology with M7 LTR and whose restriction maps were totally different one another. The DNA structures of two of them resembled the genome of retroviruses. These results suggest the presence of various types of the LTR-related sequences in human DNA: some of them might represent endogenous virus genomes of human cells.
通过非严格印迹杂交检测到与狒狒C型病毒M7的长末端重复序列（LTR）杂交的人类DNA序列。在用Eco RI、Hind III或Bam HI消化后，在来自四个独立人类细胞系的DNA中通常观察到约7至10条与LTR相关的离散条带。这些序列在肿瘤细胞系中的含量比在非恶性细胞系中更丰富。与M7 LTR相关的人类序列似乎位于细胞DNA上相对特定的位点。在Lawn等人（《细胞》15卷，1157 - 1174页，1978年）描述的人类DNA文库中检测到与M7 LTR杂交的人类DNA克隆，频率约为每单倍体基因组300个。分离出五个克隆，它们与M7 LTR具有不同程度的同源性，其限制性图谱彼此完全不同。其中两个的DNA结构类似于逆转录病毒的基因组。这些结果表明人类DNA中存在各种类型的与LTR相关的序列：其中一些可能代表人类细胞的内源性病毒基因组。
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