一种用于克服癌症多药耐药性的肿瘤特异性级联放大药物释放纳米颗粒。
A Tumor-Specific Cascade Amplification Drug Release Nanoparticle for Overcoming Multidrug Resistance in Cancers.
机构信息
Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Center for Bionanoengineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027, China.
Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
出版信息
Adv Mater. 2017 Oct;29(38). doi: 10.1002/adma.201702342. Epub 2017 Aug 21.
A cascade amplification release nanoparticle (CARN) is constructed by the coencapsulation of β-lapachone and a reactive-oxygen-species (ROS)-responsive doxorubicin (DOX) prodrug, BDOX, in polymeric nanoparticles. Releasing β-lapachone first from the CARNs selectively increases the ROS level in cancer cells via NAD(P)H:quinone oxidoreductase-1 (NQO1) catalysis, which induces the cascade amplification release of DOX and overcomes multidrug resistance (MDR) in cancer cells, producing a remarkably improved therapeutic efficacy against MDR tumors with minimal side effects.
级联放大释药纳米颗粒（CARN）是通过将β-拉帕酮和活性氧（ROS）响应性阿霉素（DOX）前药 BDOX 共包封在聚合物纳米颗粒中构建的。从 CARNs 中首先释放β-拉帕酮，通过 NAD(P)H：醌氧化还原酶-1（NQO1）催化选择性地增加癌细胞中的 ROS 水平，这诱导 DOX 的级联放大释放，并克服癌细胞中的多药耐药性（MDR），产生对 MDR 肿瘤的显著改善的治疗效果，副作用极小。
Zotero 插件