Jones D A, George N J, O'Reilly P H, Barnard R J
Lancet. 1987 May 9;1(8541):1052-4. doi: 10.1016/s0140-6736(87)90481-8.
The cardiovascular effects of relief of obstruction were examined in 21 patients with painless urinary retention and hydronephrosis and hydroureter associated with hypertension (diastolic blood pressure 95-120 mm Hg, mean 107, 11 patients), severe peripheral oedema (8 patients), raised jugular venous pressure (5 patients), or clinical evidence of pulmonary oedema (5 patients). Before relief of obstruction fractional sodium excretion was appropriate for the reduced rate of glomerular filtration. After urethral catheterisation blood pressure fell (p less than 0.001) and the other cardiovascular abnormalities were rapidly reversed without further therapeutic measures. This improvement was associated with an increase (p less than 0.05) in both absolute and fractional urinary sodium excretion that was greatest at 24 h. 5% of patients undergoing surgery for obstructive disorders of the lower urinary tract have hydronephrosis and hydroureter. Hypertension related to chronic urinary tract obstruction may be the commonest form of surgically correctable renal hypertension.
对21例无痛性尿潴留、肾积水及输尿管积水合并高血压(舒张压95 - 120 mmHg,平均107 mmHg,共11例)、重度外周水肿(8例)、颈静脉压升高(5例)或有肺水肿临床证据(5例)的患者,研究了梗阻解除后的心血管效应。在梗阻解除前,尿钠排泄分数与降低的肾小球滤过率相符。导尿后血压下降(p<0.001),且其他心血管异常在未采取进一步治疗措施的情况下迅速逆转。这种改善与尿钠排泄绝对值及分数均增加(p<0.05)相关,且在24小时时增加最为明显。接受下尿路梗阻性疾病手术的患者中有5%存在肾积水和输尿管积水。与慢性尿路梗阻相关的高血压可能是外科可纠正的肾性高血压最常见的形式。