Augusto Marina Gullo, Scaramucci Tais, Campos Tiago Moreira Bastos, Aoki Idalina Vieira, Schlueter Nadine, Borges Alessandra Bühler
Institute of Science and Technology, Department of Restorative Dentistry, São Paulo State University-UNESP, São José dos Campos 12245-000, Brazil.
School of Dentistry, Centro Universitário de Cascavel-UNIVEL, Av. Tito Muffato, 317-Santa Cruz, Cascavel 85806-080, Brazil.
Polymers (Basel). 2022 Oct 9;14(19):4225. doi: 10.3390/polym14194225.
Different agents have been proposed to prevent the progression of acid induced dental substance losses, which are called erosive tooth wear (ETW), such as fluorides, calcium, and phosphate-based products; however, there is a need for a further increase in efficacy. Recently, the ability of polymers to interact with the tooth surface, forming acid resistant films, has come into the focus of research; nevertheless, there is still the need for a better understanding of their mode of action. Thus, this article provides an overview of the chemical structure of polymers, their mode of action, as well as the effect of their incorporation into oral care products, acid beverages, and antacid formulations, targeting the prevention of ETW. Recent evidence indicates that this may be a promising approach, however, additional studies are needed to confirm their efficacy under more relevant clinical conditions that consider salivary parameters such as flow rate, composition, and clearance. The standardization of methodological procedures such as acid challenge, treatment duration, and combination with fluorides is necessary to allow further comparisons between studies. In conclusion, film-forming polymers may be a promising cost-effective approach to prevent and control erosive demineralization of the dental hard tissue.
已经提出了不同的制剂来防止酸引起的牙齿物质流失的进展，这种流失被称为侵蚀性牙齿磨损（ETW），例如氟化物、钙和磷酸盐基产品；然而，仍需要进一步提高疗效。最近，聚合物与牙齿表面相互作用形成抗酸膜的能力已成为研究的焦点；尽管如此，仍需要更好地了解它们的作用方式。因此，本文概述了聚合物的化学结构、它们的作用方式，以及将其掺入口腔护理产品、酸性饮料和抗酸制剂中对预防ETW的效果。最近的证据表明，这可能是一种有前景的方法，然而，需要更多的研究来证实它们在考虑唾液参数（如流速、成分和清除率）的更相关临床条件下的疗效。诸如酸挑战、治疗持续时间以及与氟化物联合使用等方法程序的标准化对于允许不同研究之间进行进一步比较是必要的。总之，成膜聚合物可能是一种有前景的具有成本效益的方法，用于预防和控制牙齿硬组织的侵蚀性脱矿。
