Hill David A, Leahy Allison Barz, Sciasci Joseph, O'Neill Sean P, Reilly Anne, Balamuth Naomi, Seeholzer Steven H, Spergel Jonathan M, Brown-Whitehorn Terri F
Department of Pediatrics, Division of Allergy and Immunology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Pediatr Blood Cancer. 2018 Jan;65(1). doi: 10.1002/pbc.26761. Epub 2017 Aug 22.
Vincristine (VCR) is a vinca alkaloid and common chemotherapeutic that is used to treat multiple pediatric and adult malignancies. Despite its common use, cases of anaphylaxis to VCR are rare and typically isolated to a single individual. We report a series of eight patients with adverse reactions to VCR over the course of 11 months at a single institution, four of which progressed to anaphylaxis and one of which resulted in cardiac arrest. Mass spectrometry analysis of medication lots was performed to test for possible contaminant(s). Our findings highlight the risk of anaphylaxis during therapy with VCR.
长春新碱（VCR）是一种长春花生物碱，也是一种常用的化疗药物，用于治疗多种儿童和成人恶性肿瘤。尽管其使用广泛，但对VCR过敏的病例很少见，通常仅发生在个别患者身上。我们报告了在一家机构11个月期间出现的一系列8例对VCR有不良反应的患者，其中4例进展为过敏反应，1例导致心脏骤停。对药物批次进行了质谱分析以检测可能的污染物。我们的研究结果突出了VCR治疗期间发生过敏反应的风险。
