Chang Sangah, Kim Jihyun, Sohn Taeseo, Son Hyunshik, Lee Jungmin
Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
J Int Med Res. 2018 Jan;46(1):284-292. doi: 10.1177/0300060517722697. Epub 2017 Aug 23.
Objective We evaluated the association of glucose control with changes in arterial stiffness, inflammatory markers, and oxidative stress markers. Methods Sixty-four patients with uncontrolled type 2 diabetes mellitus (glycated hemoglobin [HbA1c] ≥ 9%) and hypertension were enrolled in this study. The patients were divided into two groups based on their post-treatment HbA1c level: HbA1c ≤ 7% (well-controlled group, n = 28) and HbA1c > 7% (uncontrolled group, n = 36). The pulse wave velocity, augmentation index, and markers of inflammation and oxidative stress were measured and analyzed. Results The patients' mean baseline HbA1c level was 11.7%. There were no differences in any baseline parameters between the two groups except the duration of diabetes. The mean HbA1c level was significantly lower at 12 weeks in the well-controlled than uncontrolled group (6.1% vs. 9.0%, respectively), but there were no significant differences in the pulse wave velocity (0.33 ± 0.95 vs. 0.36 ± 1.44 m/s), aortic augmentation index (5.1 ± 8.3 vs. 0.7 ± 11.6), or markers of inflammation and oxidative stress. Conclusions Short-term glycemic control did not influence the arterial stiffness in patients with type 2 diabetes mellitus and hypertension.
目的 我们评估了血糖控制与动脉僵硬度、炎症标志物及氧化应激标志物变化之间的关联。方法 本研究纳入了64例2型糖尿病控制不佳（糖化血红蛋白[HbA1c]≥9%）且患有高血压的患者。根据治疗后HbA1c水平将患者分为两组：HbA1c≤7%（血糖控制良好组，n = 28）和HbA1c>7%（血糖控制不佳组，n = 36）。测量并分析脉搏波速度、增强指数以及炎症和氧化应激标志物。结果 患者的平均基线HbA1c水平为11.7%。除糖尿病病程外，两组间任何基线参数均无差异。血糖控制良好组在12周时的平均HbA1c水平显著低于血糖控制不佳组（分别为6.1%和9.0%），但脉搏波速度（0.33±0.95 vs. 0.36±1.44 m/s）、主动脉增强指数（5.1±8.3 vs. 0.7±11.6）或炎症和氧化应激标志物方面均无显著差异。结论 短期血糖控制对2型糖尿病合并高血压患者的动脉僵硬度无影响。
