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在多发性硬化症患者群体中,首次神经科就诊时的抑郁状态及年龄与1年内接受行为医学服务相关。

Depression and Age at First Neurology Appointment Associated with Receipt of Behavioral Medicine Services Within 1 Year in a Multiple Sclerosis Population.

作者信息

Greenberg Benjamin, Fan Youran, Carriere Lucille, Sullivan Amy

出版信息

Int J MS Care. 2017 Jul-Aug;19(4):199-207. doi: 10.7224/1537-2073.2016-012.

DOI:10.7224/1537-2073.2016-012
PMID:28835744
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5564281/
Abstract

BACKGROUND

Patients with multiple sclerosis (MS) newly seen by a neurologist may benefit from early psychological intervention owing to the reciprocal relationship between stress and disease progression. However, it is uncertain what factors contribute to patients' receiving these services.

METHODS

Logistic regression analysis of prospectively gathered data evaluated how demographic and disease characteristics and emotional/physical health factors contributed to referral to receive behavioral medicine (BM) services within 1 year of their first neurology appointment at the Mellen Center for Multiple Sclerosis at the Cleveland Clinic. Survival analyses then evaluated whether this resulted in earlier receipt of services.

RESULTS

Although many factors were associated with receiving BM services during univariate analyses (age, race, marital status, years since MS onset, depression, stress, and quality of life), when considering multivariable interactions, only two variables remained significant: age (odds ratio [OR] = 0.86, 95% confidence interval [CI], 0.80-0.92) and depression (OR = 1.56, 95% CI, 1.39-1.75). Survival analyses did not show differences in time to BM services for stratifications of age or depression scores.

CONCLUSIONS

Younger patients and patients with more severe depression were more likely to receive BM services within 1 year of their first neurology appointment. Future research will focus on evaluating whether these are also the patients in greatest need of services or whether they are simply more open to receiving them.

摘要

背景

由于压力与疾病进展之间的相互关系,神经科医生新接诊的多发性硬化症(MS)患者可能会从早期心理干预中受益。然而,尚不清楚哪些因素促使患者接受这些服务。

方法

对前瞻性收集的数据进行逻辑回归分析,评估人口统计学和疾病特征以及情绪/身体健康因素如何影响患者在克利夫兰诊所梅伦多发性硬化症中心首次神经科就诊后1年内被转诊接受行为医学(BM)服务。生存分析随后评估这是否导致更早接受服务。

结果

虽然在单变量分析中有许多因素与接受BM服务相关(年龄、种族、婚姻状况、MS发病后的年限、抑郁、压力和生活质量),但在考虑多变量相互作用时,只有两个变量仍然显著:年龄(比值比[OR]=0.86,95%置信区间[CI],0.80 - 0.92)和抑郁(OR = 1.56,95% CI,1.39 - 1.75)。生存分析未显示年龄分层或抑郁评分在接受BM服务时间上的差异。

结论

较年轻的患者和抑郁更严重的患者在首次神经科就诊后1年内更有可能接受BM服务。未来的研究将集中评估这些患者是否也是最需要服务的患者,或者他们是否只是更愿意接受服务。