Developmental Neurobiology, Kyoto Prefectural University of Medicine, INAMORI Memorial Building, 1-5 Shimogamo-hangi cho, Sakyoku, Kyoto, 606-0823, Japan.
Neurochem Res. 2018 Jan;43(1):162-165. doi: 10.1007/s11064-017-2380-z. Epub 2017 Aug 24.
Understanding the fate commitment of neural stem cells is critical to identify the regulatory mechanisms in developing brains. Genetic lineage-tracing has provided a powerful strategy to unveil the heterogeneous nature of stem cells and their descendants. However, recent studies have reported controversial data regarding the heterogeneity of neural stem cells in the developing mouse neocortex, which prevents a decisive conclusion on this issue. Here, we review the progress that has been made using lineage-tracing analyses of the developing neocortex and discuss stem cell heterogeneity from the viewpoint of comparative and evolutionary biology.
了解神经干细胞的命运决定对于识别发育中大脑的调控机制至关重要。遗传谱系追踪为揭示干细胞及其后代的异质性提供了一种强大的策略。然而，最近的研究报告了关于发育中小鼠新皮层中神经干细胞异质性的有争议的数据，这使得在这个问题上无法得出决定性的结论。在这里，我们回顾了使用发育中的新皮层的谱系追踪分析所取得的进展，并从比较和进化生物学的角度讨论了干细胞的异质性。
