吉西他滨和顺铂化疗后双侧黄斑梗死
Bilateral macular infarction after gemcitabine and carboplatin chemotherapy.
作者信息
Behera Umesh Chandra, Modi Rohit R, Sheth Jenil, Singh Arshi
机构信息
L V Prasad Eye Institute, Patia, Bhubaneswar, Odisha, 751024, India.
出版信息
Int Ophthalmol. 2018 Oct;38(5):2195-2198. doi: 10.1007/s10792-017-0698-9. Epub 2017 Aug 23.
PURPOSE
To report a case of macular infarction after doublet chemotherapy with gemcitabine and carboplatin.
METHODS
A middle-aged lady presenting with bilateral macular infarction post-chemotherapy for metastatic cervical malignancy was investigated for thromboembolic risks and treated.
RESULTS
The macular perfusion and edema improved with control of hypertension and treatment with pentoxifylline. Visual improvement was satisfactory, and the possible associated risk such as hypertension was noted.
CONCLUSION
This case underscores the need for active screening of patients on chemotherapy with gemcitabine and carboplatin for retinal vascular occlusive changes when hypertension is associated.
目的
报告1例吉西他滨和顺铂双联化疗后发生黄斑梗死的病例。
方法
对1例转移性宫颈恶性肿瘤化疗后出现双侧黄斑梗死的中年女性进行血栓栓塞风险调查并给予治疗。
结果
通过控制高血压及己酮可可碱治疗，黄斑灌注及水肿得到改善。视力改善情况良好，并注意到可能存在的相关风险，如高血压。
结论
该病例强调，对于合并高血压且接受吉西他滨和顺铂化疗的患者，有必要积极筛查视网膜血管闭塞性改变。
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