Department of Hygiene Inspection and Quarantine Science, Center for Hygiene Testing and Analysis, School of Public Health, Southern Medical University, North 1838th Guangzhou Avenue, Guangzhou, Guangdong, 510515, China.
Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, Guangdong, 510515, China.
Environ Sci Pollut Res Int. 2017 Oct;24(29):23299-23308. doi: 10.1007/s11356-017-9922-4. Epub 2017 Aug 24.
To evaluate the exposure of children to 14 perfluorinated compounds (PFCs) in a typical and representative industrial city, plasma samples from 476 children aged 0-7 years in Foshan, China, were analysed. Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) were detected in 100% of the samples, accounting for 82.27 and 11.46% of the total PFC concentrations, respectively, while PFOS peaked at age 0-1 years, for which the mean and median concentrations were 113.71 and 83.65 ng/mL, respectively, while PFOA peaked at age 3-4 years, for which the mean and median concentrations were 10.68 and 6.58 ng/mL, respectively. The concentrations of PFOS, perfluorohexane sulfonate and perfluorohexanoic acid decreased with age among children aged 0-7 years, and no gender-related differences were found in the concentrations of PFCs. A high correlation was found among all PFCs, especially between PFCs of similar carbon chains (r = 0.161-0.695, p < 0.05). In addition, the concentrations of PFOS and PFOA in children's plasma in Foshan were up to 40-fold higher than those reported in China and other countries. In conclusion, children in Foshan have extensive exposure to PFCs, especially in infancy. Further studies are needed to explore the impact of PFCs on children who live in a typical and representative industrial city in China. Graphical abstract ᅟ.
为了评估典型代表性工业城市中儿童接触 14 种全氟化合物（PFCs）的情况，对来自中国佛山 476 名 0-7 岁儿童的血浆样本进行了分析。在所有样本中均检测到全氟辛烷磺酸（PFOS）和全氟辛酸（PFOA），分别占总 PFC 浓度的 82.27%和 11.46%，而 PFOS 在 0-1 岁时浓度最高，均值和中位数浓度分别为 113.71 和 83.65ng/mL，而 PFOA 在 3-4 岁时浓度最高，均值和中位数浓度分别为 10.68 和 6.58ng/mL。0-7 岁儿童的 PFOS、全氟己烷磺酸和全氟己酸浓度随年龄增长而降低，且 PFC 浓度在性别间无差异。所有 PFC 之间存在高度相关性，尤其是具有相似碳链的 PFC 之间（r=0.161-0.695，p<0.05）。此外，佛山儿童血浆中 PFOS 和 PFOA 的浓度比中国和其他国家报道的浓度高 40 倍。总之，佛山儿童广泛接触 PFCs，尤其是在婴儿期。需要进一步研究以探讨 PFCs 对生活在中国典型代表性工业城市的儿童的影响。
