School of Science, Shenyang University of Technology, Shenyang, 110870, China.
Environ Sci Pollut Res Int. 2014 Jun;21(12):7650-5. doi: 10.1007/s11356-014-2594-4. Epub 2014 Mar 13.
Severe perfluoroalkyl acid (PFAA) contamination resulting from the fast-growing semiconductor, electrochemical, and optoelectronic industries has been determined in the river water in the vicinity of the Taipei area, Taiwan, during recent years. However, little is known about body burdens of the PFAA contaminations in local residents, especially children living in the Taipei area recently. In this study, ten target PFAA analytes consisted of three perfluorosulfonates (PFSAs) and seven perfluorocarboxylates (PFCAs) in the blood serum samples, collected from 225 healthy children with an average age of 13.6 years in the Taipei area from 2009 to 2010, were analyzed via high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). As the dominant PFAA contaminant in the blood serum samples from Taiwanese children, perfluorooctane sulfonate (PFOS) contributed 86% of all the target PFAA analytes, while the other nine analytes contributed less than 5% individually. PFOS showed the highest median up to 29 ng/mL, ranging from 0.03 to 148 ng/mL, which was higher than that observed in the serum samples collected from Taiwanese children between 2006 and 2008. Statistically, serum concentrations of perfluorobutane sulfonate (PFBS), perfluorohexane sulfonate (PFHxS), and perfluorooctanoic acid (PFOA) had significantly positive correlations with ages of children (p < 0.05). Furthermore, serum PFBS, PFHxS, and PFOA concentrations in the male children were considerably higher than those in the female children (p = 0.049, p = 0.000, p = 0.000).
近年来，在台湾台北地区附近的河水中发现了严重的全氟羧酸（PFCAs）和全氟磺酸（PFSA）污染，这与快速发展的半导体、电化学和光电工业有关。然而，对于当地居民，尤其是最近居住在台北地区的儿童体内的 PFAA 污染负荷，人们知之甚少。在这项研究中，分析了 2009 年至 2010 年间采集的 225 名平均年龄为 13.6 岁的台北地区健康儿童血清样本中的 10 种目标 PFAA 分析物，包括 3 种全氟磺酸（PFSAs）和 7 种全氟羧酸（PFCAs），使用高效液相色谱-串联质谱法（HPLC-MS/MS）进行分析。作为台湾儿童血液样本中主要的 PFAA 污染物，全氟辛烷磺酸（PFOS）占所有目标 PFAA 分析物的 86%，而其他 9 种分析物各自的贡献都低于 5%。PFOS 的中位数最高，达到 29ng/mL，范围为 0.03-148ng/mL，高于 2006 年至 2008 年间采集的台湾儿童血清样本中的浓度。统计学分析显示，血清中全氟丁烷磺酸（PFBS）、全氟己烷磺酸（PFHxS）和全氟辛酸（PFOA）的浓度与儿童年龄呈显著正相关（p<0.05）。此外，男童血清 PFBS、PFHxS 和 PFOA 浓度明显高于女童（p=0.049、p=0.000、p=0.000）。
