Cruz Letícia L, Mota Sara J, Catarino Isabel P, Cardoso Helder P
Anesthesiology, Unidade Local de Saúde do Tâmega e Sousa, E.P.E., Penafiel, PRT.
Orthopedics, Unidade Local de Saúde do Tâmega e Sousa, E.P.E., Penafiel, PRT.
Cureus. 2025 Mar 8;17(3):e80249. doi: 10.7759/cureus.80249. eCollection 2025 Mar.
This study examines the efficacy of botulinum neurotoxin type A (BoNT-A) in neuropathic pain management. Neuropathic pain (NP) is a chronic condition that remains challenging to treat. While botulinum neurotoxin type A (BoNT-A) has been proposed as a therapeutic option, its efficacy in trauma-induced NP remains unclear. This report presents two patients with NP in their fingers - one following a traumatic amputation and the other a sharp laceration - who underwent two sessions of BoNT-A injections. Neither patient experienced improvement in pain severity or functionality, and severe allodynia persisted. These findings suggest that BoNT-A may have limited efficacy in certain neuropathic pain conditions, emphasizing the need for careful patient selection and further research into alternative therapeutic strategies. Additionally, this study introduces the "neuropathic finger" as a model for investigating local drugs with potential antineuropathic properties.
本研究考察了A型肉毒杆菌神经毒素（BoNT-A）在神经性疼痛管理中的疗效。神经性疼痛（NP）是一种慢性疾病，治疗起来仍然具有挑战性。虽然A型肉毒杆菌神经毒素（BoNT-A）已被提议作为一种治疗选择，但其在创伤性NP中的疗效仍不明确。本报告介绍了两名手指患有NP的患者——一名是创伤性截肢后，另一名是锐器割伤后——他们接受了两次BoNT-A注射。两名患者的疼痛严重程度和功能均未改善，严重的异常性疼痛持续存在。这些发现表明，BoNT-A在某些神经性疼痛情况下的疗效可能有限，强调了仔细选择患者的必要性以及对替代治疗策略进行进一步研究的必要性。此外，本研究引入了“神经性手指”作为一种模型，用于研究具有潜在抗神经病变特性的局部药物。
