Grillo A P, Fraunfelder F W
Department of Ophthalmology, Mason Eye Institute, University of Missouri School of Medicine, Columbia, Missouri, USA.
Drugs Today (Barc). 2017 Jul;53(7):393-397. doi: 10.1358/dot.2017.53.7.2667582.
The objective of this review was to collect reports of keratitis in association with herpes zoster virus (HZV) or varicella zoster virus (VZV) vaccines. HZV vaccination is intended for at-risk adult populations and VZV vaccination is intended for all pediatric patients. We reviewed the literature and reports of keratitis in association with herpes zoster or varicella vaccine from the National Registry of Drug-Induced Ocular Side Effects and the World Health Organization. Twenty-four cases of unilateral keratitis in association with VZV vaccines were collected from the adverse reaction databases and literature. In most cases, the onset of keratitis occurred within days of vaccination and resolved with topical steroid eye drops and oral acyclovir. Data suggest that keratitis in association with herpes zoster or varicella vaccine is rare, is usually self-limited or resolves with treatment. The mechanism may be the persistence of viral antigens in the cornea after VZV vaccination or herpes zoster ophthalmicus. This reaction is probable, given the plausible biological mechanism, the temporal relationship between vaccination and keratitis, and overall patterns of presentation after vaccination.
本综述的目的是收集与带状疱疹病毒（HZV）或水痘-带状疱疹病毒（VZV）疫苗相关的角膜炎报告。HZV疫苗用于高危成年人群，VZV疫苗用于所有儿科患者。我们查阅了来自国家药物性眼部副作用登记处和世界卫生组织的与带状疱疹或水痘疫苗相关的角膜炎文献及报告。从不良反应数据库和文献中收集到24例与VZV疫苗相关的单侧角膜炎病例。在大多数情况下，角膜炎在接种疫苗数天内发病，使用局部类固醇眼药水和口服阿昔洛韦后病情缓解。数据表明，与带状疱疹或水痘疫苗相关的角膜炎很罕见，通常为自限性或经治疗后可缓解。其机制可能是VZV疫苗接种后或眼部带状疱疹后病毒抗原在角膜持续存在。鉴于合理的生物学机制、接种疫苗与角膜炎之间的时间关系以及接种疫苗后的总体表现模式，这种反应是有可能发生的。
