Kim Jihye, Kim Keun Ho, Lee Bum Ju
KM Fundamental Research Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea.
PLoS One. 2017 Aug 24;12(8):e0183777. doi: 10.1371/journal.pone.0183777. eCollection 2017.
Peptic ulcer disease (PUD) is a common disorder, but whether an association exists between PUD and anthropometric indicators remains controversial. Furthermore, no studies on the association of PUD with anthropometric indices, blood parameters, and nutritional components have been reported. The aim of this study was to assess associations of anthropometrics, blood parameters, nutritional components, and lifestyle factors with PUD in the Korean population.
Data were collected from a nationally representative sample of the South Korean population using the Korea National Health and Nutrition Examination Survey. Logistic regression was used to examine associations of anthropometrics, blood parameters and nutritional components among patients with PUD.
Age was the factor most strongly associated with PUD in women (p = <0.0001, odds ratio (OR) = 0.770 [0.683-0.869]) and men (p = <0.0001, OR = 0.715 [0.616-0.831]). In both crude and adjusted analyses, PUD was highly associated with weight (adjusted p = 0.0008, adjusted OR = 1.251 [95%CI: 1.098-1.426]), hip circumference (adjusted p = 0.005, adjusted OR = 1.198 [1.056-1.360]), and body mass index (adjusted p = 0.0001, adjusted OR = 1.303 [1.139-1.490]) in women and hip circumference (adjusted p = 0.0199, adjusted OR = 1.217 [1.031-1.435]) in men. PUD was significantly associated with intake of fiber (adjusted p = 0.0386, adjusted OR = 1.157 [1.008-1.328], vitamin B2 (adjusted p = 0.0477, adjusted OR = 1.155 [1.001-1.333]), sodium (adjusted p = 0.0154, adjusted OR = 1.191 [1.034-1.372]), calcium (adjusted p = 0.0079, adjusted OR = 1.243 [1.059-1.459]), and ash (adjusted p = 0.0468, adjusted OR = 1.152 [1.002-1.325] in women but not in men. None of the assessed blood parameters were associated with PUD in women, and only triglyceride level was associated with PUD in men (adjusted p = 0.0169, adjusted OR = 1.227 [1.037-1.451]).
We found that obesity was associated with PUD in the Korean population; additionally, the association between nutritional components and PUD was greater in women than in men.
消化性溃疡病（PUD）是一种常见疾病，但PUD与人体测量指标之间是否存在关联仍存在争议。此外，尚未有关于PUD与人体测量指数、血液参数及营养成分之间关联的研究报道。本研究旨在评估韩国人群中人体测量学、血液参数、营养成分及生活方式因素与PUD之间的关联。
使用韩国国家健康与营养检查调查从韩国具有全国代表性的人群样本中收集数据。采用逻辑回归分析来检验PUD患者中人体测量学、血液参数和营养成分之间的关联。
年龄是与女性（p = <0.0001，比值比（OR）= 0.770 [0.683 - 0.869]）和男性（p = <0.0001，OR = 0.715 [0.616 - 0.831]）的PUD关联最密切的因素。在粗分析和校正分析中，PUD与女性的体重（校正p = 0.0008，校正OR = 1.251 [95%CI：1.098 - 1.426]）、臀围（校正p = 0.005，校正OR = 1.198 [1.056 - 1.360]）和体重指数（校正p = 0.0001，校正OR = 1.303 [1.139 - 1.490]）以及男性的臀围（校正p = 0.0199，校正OR = 1.217 [1.031 - 1.435]）高度相关。PUD与女性的纤维摄入量（校正p = 0.0386，校正OR = 1.157 [1.008 - 1.328]）、维生素B2（校正p = 0.0477，校正OR = 1.155 [1.001 - 1.333]）、钠（校正p = 0.0154，校正OR = 1.191 [1.034 - 1.372]）、钙（校正p = 0.0079，校正OR = 1.243 [1.059 - 1.459]）和灰分（校正p = 0.0468，校正OR = 1.152 [1.002 - 1.325]）显著相关，但与男性无关。评估的血液参数中，没有一个与女性的PUD相关，只有甘油三酯水平与男性的PUD相关（校正p = 0.0169，校正OR = 1.227 [1.037 - 1.451]）。
我们发现肥胖与韩国人群的PUD相关；此外，营养成分与PUD之间的关联在女性中比在男性中更强。
