在一项大型台湾人群研究中，高肥胖指数与胃食管反流病相关，而低肥胖指数与消化性溃疡病相关。

High Obesity Indices Are Associated with Gastroesophageal Reflux Disease, but Low Obesity Indices Are Associated with Peptic Ulcer Disease in a Large Taiwanese Population Study.

机构信息

Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

出版信息

Obes Facts. 2024;17(5):491-501. doi: 10.1159/000540281. Epub 2024 Jul 18.

DOI:10.1159/000540281

PMID:39008955

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11458163/

Abstract

INTRODUCTION

Gastroesophageal reflux disease (GERD) and peptic ulcer disease (PUD) are prevalent in Taiwan. Few studies have investigated the associations between obesity indices with GERD and PUD simultaneously. This study aimed to investigate the correlations among obesity indices with GERD and PUD in a large cohort of participants, around 120,000, in the Taiwan Biobank (TWB).

METHODS

A total of 121,583 participants (male: 43,698; female: 77,885; mean age 49.9 ± 11.0 years) were included to analyze the associations among obesity indices, including body mass index (BMI), waist-hip ratio (WHR), waist-to-height ratio (WHtR), body roundness index (BRI), abdominal volume index (AVI), lipid accumulation product (LAP), visceral adiposity index (VAI), and triglyceride-glucose index (TyG index), with GERD and PUD. Self-reported GERD and PUD were obtained by questionnaires. Multivariate logistic regression analysis was employed to analyze the relationship between obesity indices with GERD and PUD.

RESULTS

The prevalence of GERD and PUD was 13.7% and 14.6%, respectively. After multivariable analysis, high WHR (odds ratio [OR] = 1.009, p < 0.001), WHtR (OR = 1.005, p = 0.003), BRI (OR = 1.022, p = 0.005), AVI (OR = 1.013, p < 0.001), LAP (OR = 1.001, p < 0.001), TyG index (OR = 1.068, p < 0.001), and VAI (OR = 1.013, p = 0.002) were significantly associated with GERD, except BMI (p = 0.384). On the other hand, low BMI (OR = 0.984; p < 0.001) and AVI (OR = 0.994; p = 0.036) were significantly associated with PUD. However, the values of WHR (p = 0.151), WHtR (p = 0.304), BRI (p = 0.452), LAP (p = 0.799), VAI (p = 0.347), and TyG index (p = 0.642) were not.

CONCLUSION

This study found that high obesity indices are associated with GERD, but low obesity indices are associated with PUD in a large Taiwanese population study. Our findings may alert physicians to notice that different obesity index may be associated with different gastrointestinal disorder.

摘要

简介

胃食管反流病（GERD）和消化性溃疡病（PUD）在台湾很常见。很少有研究同时调查肥胖指数与 GERD 和 PUD 之间的关系。本研究旨在探讨肥胖指数与 GERD 和 PUD 之间的相关性，研究对象为台湾生物银行（TWB）的 120000 多名参与者。

方法

共纳入 121583 名参与者（男性：43698 名；女性：77885 名；平均年龄 49.9±11.0 岁），分析肥胖指数（包括体重指数（BMI）、腰臀比（WHR）、腰高比（WHtR）、体圆度指数（BRI）、腹围指数（AVI）、脂质蓄积产物（LAP）、内脏脂肪指数（VAI）和甘油三酯-葡萄糖指数（TyG 指数）与 GERD 和 PUD 的关系。通过问卷获得 GERD 和 PUD 的自我报告。采用多变量 logistic 回归分析肥胖指数与 GERD 和 PUD 的关系。

结果

GERD 和 PUD 的患病率分别为 13.7%和 14.6%。多变量分析后，高 WHR（比值比[OR] = 1.009，p < 0.001）、WHtR（OR = 1.005，p = 0.003）、BRI（OR = 1.022，p = 0.005）、AVI（OR = 1.013，p < 0.001）、LAP（OR = 1.001，p < 0.001）、TyG 指数（OR = 1.068，p < 0.001）和 VAI（OR = 1.013，p = 0.002）与 GERD 显著相关，BMI 除外（p = 0.384）。另一方面，低 BMI（OR = 0.984；p < 0.001）和 AVI（OR = 0.994；p = 0.036）与 PUD 显著相关。然而，WHR（p = 0.151）、WHtR（p = 0.304）、BRI（p = 0.452）、LAP（p = 0.799）、VAI（p = 0.347）和 TyG 指数（p = 0.642）的值没有。