Miyake Kazumasa, Akimoto Teppei, Kusakabe Makoto, Sato Wataru, Yamada Akiyoshi, Yamawaki Hiroshi, Kodaka Yasuhiro, Shinpuku Mayumi, Nagoya Hiroyuki, Shindo Tomotaka, Ueki Nobue, Kusunoki Masafumi, Kawagoe Tetsuro, Futagami Seiji, Tsukui Taku, Sakamoto Choitsu
Department of Gastroenterology, Nippon Medical School.
J Nutr Sci Vitaminol (Tokyo). 2013;59(6):503-8. doi: 10.3177/jnsv.59.503.
We investigated over time whether contemporary Japanese patients with complicated peptic ulcers have any water-soluble vitamin deficiencies soon after the onset of the complicated peptic ulcers. In this prospective cohort study, fasting serum levels of water-soluble vitamins (vitamins B1, B2, B6, B12, C, and folic acid) and homocysteine were measured at 3 time points (at admission, hospital discharge, and 3 mo after hospital discharge). Among the 20 patients who were enrolled in the study, 10 consecutive patients who completed measurements at all 3 time points were analyzed. The proportion of patients in whom any of the serum water-soluble vitamins that we examined were deficient was as high as 80% at admission, and remained at 70% at discharge. The proportion of patients with vitamin B6 deficiency was significantly higher at admission and discharge (50% and 60%, respectively, p<0.05) than at 3 mo after discharge (10%). In conclusion, most patients with complicated peptic ulcers may have a deficiency of one or more water-soluble vitamins in the early phase of the disease after the onset of ulcer complications, even in a contemporary Japanese population.
