Wilkins J, Chan L S, Wehrle P F
Vaccine. 1987 Mar;5(1):49-54. doi: 10.1016/0264-410x(87)90009-0.
The agglutinin response to pertussis agglutinogens in diphtheria-tetanus-pertussis (DTP) vaccine was determined in human infants inoculated initially at ages four weeks to eight months. The effects of age at the time of initial dose and the interval between subsequent doses were specifically evaluated. Our findings demonstrate that optimum agglutinin production is best achieved with DTP vaccine by beginning immunization at five months of age or later followed by a second dose at eight weeks or more. Variation in the two variables, age and dose interval, decreases the likelihood of an optimum agglutinin response.
对白喉-破伤风-百日咳（DTP）疫苗中百日咳凝集原的凝集素反应，在最初于4周龄至8月龄接种疫苗的人类婴儿中进行了测定。具体评估了首次接种时的年龄以及后续剂量之间的间隔的影响。我们的研究结果表明，通过在5月龄或更大年龄开始免疫接种，随后在8周或更长时间后接种第二剂，使用DTP疫苗能最佳地实现凝集素的产生。这两个变量（年龄和剂量间隔）的变化会降低获得最佳凝集素反应的可能性。
