Division of Colon and Rectal Surgery, Mayo Clinic, 200 1st Street Southwest, Rochester, MN 55905, USA.
Division of Gastroenterology, Mayo Clinic, 200 1st Street Southwest, Rochester, MN 55905, USA.
Gastroenterol Clin North Am. 2017 Sep;46(3):547-562. doi: 10.1016/j.gtc.2017.05.008.
Perianal disease is a common manifestation of Crohn disease (CD) that results in significant morbidity and decreased quality of life. Despite several medical and surgical options, complex perianal CD remains difficult to treat. Before the advent of biologic therapy, antibiotics were the mainstay of medical treatment. Infliximab remains the most well-studied medical therapy for perianal disease. Surgical interventions are limited by the risk of nonhealing wounds and potential incontinence. When treatment options fail, fecal diversion or proctectomy may be necessary. Stem cell therapies may offer improved results and seem to be safe, but are not yet widely used.
肛周疾病是克罗恩病（CD）的一种常见表现，可导致显著的发病率和生活质量下降。尽管有多种医疗和手术选择，但复杂的肛周 CD 仍然难以治疗。在生物治疗出现之前，抗生素是肛周疾病的主要治疗方法。英夫利昔单抗仍然是治疗肛周疾病最广泛研究的医学治疗方法。手术干预受到非愈合伤口和潜在失禁风险的限制。当治疗选择失败时，粪便转流或直肠切除术可能是必要的。干细胞疗法可能提供更好的结果，而且似乎是安全的，但尚未广泛应用。
