脐带间充质干细胞输注所致血栓栓塞：2例报告及文献复习
Thromboembolism Induced by Umbilical Cord Mesenchymal Stem Cell Infusion: A Report of Two Cases and Literature Review.
作者信息
Wu Z, Zhang S, Zhou L, Cai J, Tan J, Gao X, Zeng Z, Li D
机构信息
Department of Hepatobiliary Disease, Fuzhou General Hospital (Donfang Hospital), Xiamen University, Fuzhou, China.
Organ Transplant Institute, Fuzhou General Hospital (Dongfang Hospital), Xiamen University, Fuzhou, China.
出版信息
Transplant Proc. 2017 Sep;49(7):1656-1658. doi: 10.1016/j.transproceed.2017.03.078.
OBJECTIVE
To investigate the thromboembolism induced by blood-mediated inflammatory reactions against infused cells during the clinical application of stem cells.
METHODS
Two patients with renal transplantation and chronic kidney disease, respectively, experienced thromboembolism after umbilical cord mesenchymal stem cell (UCMSC) infusion. The clinical manifestations and the laboratory test results were collected and analyzed.
RESULTS
The patients received stem cell infusion through the peripheral veins and presented with a swollen and painful forearm postinfusion. Doppler ultrasound showed venous clots at the proximal end of the puncture site. Urokinase and warfarin were used for thrombolytic therapy. The swelling and pain were relieved and cured.
CONCLUSION
Safety concerns are still a primary hurdle for stem cell therapy, and thromboembolism as a critical complication should be prevented appropriately.
目的
研究干细胞临床应用过程中，血液介导的针对输注细胞的炎症反应所引发的血栓栓塞。
方法
两名分别患有肾移植和慢性肾病的患者，在输注脐带间充质干细胞（UCMSC）后发生血栓栓塞。收集并分析临床表现和实验室检查结果。
结果
患者通过外周静脉输注干细胞，输注后前臂出现肿胀和疼痛。多普勒超声显示穿刺部位近端有静脉血栓。使用尿激酶和华法林进行溶栓治疗。肿胀和疼痛得以缓解并治愈。
结论
安全问题仍是干细胞治疗的主要障碍，作为一种严重并发症的血栓栓塞应得到适当预防。
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