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成人炎症性肠病的营养管理:现有证据中的实用经验教训。

Nutritional management of adults with inflammatory bowel disease: practical lessons from the available evidence.

作者信息

Smith Melissa A, Smith Trevor, Trebble Timothy M

机构信息

Department of Gastroenterology, Guy's and St Thomas' NHS Foundation Trust, London, UK.

Department of Gastroenterology and Human Nutrition, Southampton University Hospitals Trust, Southampton General Hospital, Southampton, UK.

出版信息

Frontline Gastroenterol. 2012 Jul;3(3):172-179. doi: 10.1136/flgastro-2011-100032. Epub 2012 May 21.

DOI:10.1136/flgastro-2011-100032
PMID:28839660
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5517270/
Abstract

Inflammatory bowel disease (IBD) is associated with impairment of nutritional status both anthropometrically and biochemically, which results from both qualitative and quantitative changes in dietary intake alongside disease activity. Dietary intervention to replace deficiency is essential and may also be used to treat active disease and to reduce symptoms. The evidence for dietary interventions in this area is reviewed and the following recommendations made: ■Assessment of nutritional status is an essential part of the investigation of all patients with IBD and deficiency should be actively sought.■Any patient with macro- or micronutrient deficiency should be referred for dietetic assessment.■Micronutrient deficiency (most frequently iron, vitamin B12, folate and magnesium) should be replaced aggressively, parenterally if necessary.■Significant improvement in gastrointestinal symptoms can be achieved by low-residue diets (for stricturing disease) and (always under dietetic supervision) management of lactose and other intolerances.■Irritable bowel syndrome symptoms in patients with IBD can respond to low fermentable oligo-, di-, monosaccharide and polyol (FODMAP) diets, again this must be done under dietetic supervision.■Active Crohn's disease can be treated by exclusive enteral nutrition (elemental/polymeric/altered fat formulations all have equivalent efficacy).■Enteral nutrition can maintain remission in Crohn's disease and in this context can be given alongside normal oral intake.■Nutritional support does not have an established role in the treatment of active ulcerative colitis, other than in the management of malnutrition.■Total parenteral nutrition should not be used unless intestinal failure occurs.■There is insufficient evidence to support the routine use of Ω3 fish oil, prebiotics and glutamine in the treatment of active IBD.

摘要

炎症性肠病(IBD)在人体测量学和生物化学方面均与营养状况受损相关,这是由饮食摄入量的质和量的变化以及疾病活动共同导致的。通过饮食干预来补充营养不足至关重要,并且饮食干预还可用于治疗活动性疾病和减轻症状。本文对该领域饮食干预的证据进行了综述,并提出以下建议:

  • 营养状况评估是所有IBD患者检查的重要组成部分,应积极寻找营养缺乏情况。

  • 任何患有宏量或微量营养素缺乏的患者都应转诊进行饮食评估。

  • 微量营养素缺乏(最常见的是铁、维生素B12、叶酸和镁)应积极补充,必要时可采用肠外补充。

  • 低渣饮食(用于狭窄性疾病)以及(始终在饮食指导下)对乳糖和其他不耐受情况的管理可显著改善胃肠道症状。

  • IBD患者的肠易激综合征症状对低可发酵寡糖、双糖、单糖和多元醇(FODMAP)饮食有反应,同样,这必须在饮食指导下进行。

  • 活动性克罗恩病可通过全肠内营养进行治疗(要素膳/聚合膳/改变脂肪配方均具有同等疗效)。

  • 肠内营养可维持克罗恩病的缓解,在这种情况下可与正常口服摄入同时进行。

  • 除了营养不良的管理外,营养支持在活动性溃疡性结肠炎的治疗中没有既定作用。

  • 除非发生肠衰竭,否则不应使用全肠外营养。

  • 没有足够的证据支持常规使用Ω-3鱼油、益生元和谷氨酰胺治疗活动性IBD。

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本文引用的文献

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Smokers with active Crohn's disease have a clinically relevant dysbiosis of the gastrointestinal microbiota.活动性克罗恩病患者的胃肠道微生物群存在临床相关的菌群失调。
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Enteral nutrition decreases hospitalization rate in patients with Crohn's disease.肠内营养可降低克罗恩病患者的住院率。
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Does evidence exist to include dietary therapy in the treatment of Crohn's disease?膳食疗法是否可作为克罗恩病的一种治疗方法,有相关证据吗?
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Prospective clinical trial: enteral nutrition during maintenance infliximab in Crohn's disease.前瞻性临床试验:克罗恩病维持期使用英夫利昔单抗时的肠内营养。
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