Garrick Vikki, Stenhouse Emily, Haddock Graham, Russell Richard K
Department of Paediatric Gastroenterology, Royal Hospital for Sick Children, Yorkhill Hospital, Glasgow, UK.
Department of Paediatric Radiology, Royal Hospital for Sick Children, Yorkhill Hospital, Glasgow, UK.
Frontline Gastroenterol. 2013 Apr;4(2):152-160. doi: 10.1136/flgastro-2012-100160. Epub 2012 Dec 14.
Crohn's disease (CD) is characterised by periods of relapse and remission. Over time the disease leads almost inevitably to the complications of stricturing, penetration and fistulisation. Perianal CD involves areas of chronic abscess formation, ulceration, skin tags or fistula formation. This can be a particularly challenging and complex problem to manage, and a range of potential treatment modalities exist.
This review covers the management of perianal CD and provides recommendations for practice for the multidisciplinary team (MDT), including the use of wound management products and relevant clinical images.
Current practice focuses predominantly on the use of antibiotic therapy, immunosuppression, immunomodulation and surgery. These therapies are used individually or in combination. The majority of evidence suggests that a combination of medical and surgical management produces the best disease outcomes. However, this treatment regime can be debilitating for the patient and compliance can be difficult. Published work on the use of topical therapy in the management of perianal CD focuses specifically on topical drug therapy; it does not, however, address the basic guiding principles of chronic wound management-in particular, optimal moisture control and the management of bacterial burden on the wound surface. Honey and silver-containing wound management products act as topical antimicrobial agents and therefore address these principles.
Perianal CD is the archetypal condition that exemplifies the need for an MDT approach in caring for patients with inflammatory bowel disease. A combination of treatment modalities that includes topical wound management is likely to produce the best patient outcomes.
克罗恩病(CD)的特点是病情有复发和缓解期。随着时间推移,该病几乎不可避免地会导致狭窄、穿透和瘘管形成等并发症。肛周克罗恩病涉及慢性脓肿形成、溃疡、皮赘或瘘管形成区域。这可能是一个特别具有挑战性和复杂的管理问题,并且存在一系列潜在的治疗方式。
本综述涵盖肛周克罗恩病的管理,并为多学科团队(MDT)提供实践建议,包括伤口管理产品的使用和相关临床图像。
目前的实践主要集中在使用抗生素治疗、免疫抑制、免疫调节和手术。这些疗法单独或联合使用。大多数证据表明,药物和手术联合管理能产生最佳的疾病治疗效果。然而,这种治疗方案可能使患者虚弱,且依从性可能较差。关于局部治疗在肛周克罗恩病管理中的应用的已发表研究专门关注局部药物治疗;然而,它并未涉及慢性伤口管理的基本指导原则——特别是最佳湿度控制和伤口表面细菌负荷的管理。含蜂蜜和银的伤口管理产品作为局部抗菌剂,因此符合这些原则。
肛周克罗恩病是典型病例,体现了在照顾炎症性肠病患者时采用多学科团队方法的必要性。包括局部伤口管理在内的多种治疗方式的组合可能会为患者带来最佳治疗效果。