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Clin Exp Immunol. 2010 Sep;161(3):417-25. doi: 10.1111/j.1365-2249.2010.04184.x.
2
Dynamics of celiac disease-specific serology after initiation of a gluten-free diet and use in the assessment of compliance with treatment. gluten-free 饮食开始后和用于评估治疗依从性时乳糜泻特异性血清学的动态变化。
Dig Liver Dis. 2010 May;42(5):352-8. doi: 10.1016/j.dld.2009.07.011. Epub 2009 Aug 12.
3
Population screening for coeliac disease in primary care by district nurses using a rapid antibody test: diagnostic accuracy and feasibility study.地区护士在初级医疗保健中使用快速抗体检测进行乳糜泻人群筛查：诊断准确性和可行性研究。
BMJ. 2007 Dec 15;335(7632):1244-7. doi: 10.1136/bmj.39405.472975.80. Epub 2007 Dec 6.
4
Performance of a new rapid whole blood coeliac test in adult patients with low prevalence of endomysial antibodies.
Dig Liver Dis. 2007 Dec;39(12):1057-63. doi: 10.1016/j.dld.2007.09.005. Epub 2007 Nov 5.
5
American Gastroenterological Association (AGA) Institute technical review on the diagnosis and management of celiac disease.美国胃肠病学会（AGA）研究所关于乳糜泻诊断与管理的技术综述。
Gastroenterology. 2006 Dec;131(6):1981-2002. doi: 10.1053/j.gastro.2006.10.004.
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7
Coeliac disease case finding and diet monitoring by point-of-care testing.通过即时检测进行乳糜泻病例筛查和饮食监测。
Aliment Pharmacol Ther. 2005 Oct 15;22(8):729-37. doi: 10.1111/j.1365-2036.2005.02663.x.
8
Seroprevalence, correlates, and characteristics of undetected coeliac disease in England.英国未被检测出的乳糜泻的血清流行率、相关因素及特征
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9
The histopathology of coeliac disease: time for a standardized report scheme for pathologists.乳糜泻的组织病理学：为病理学家制定标准化报告方案的时候了。
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Identification of tissue transglutaminase as the autoantigen of celiac disease.鉴定组织转谷氨酰胺酶为乳糜泻的自身抗原。
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近患者乳糜泻血清学检测在乳糜泻患者随访中的作用。

The role of near-patient coeliac serology testing in the follow-up of patients with coeliac disease.

作者信息

George D A, Hui L L, Rattehalli D, Lovatt T, Perry I, Green M, Robinson K, Walters J R F, Brookes M J

机构信息

Department of Gastroenterology, New Cross Hospital, Wolverhampton, UK.

Department of Gastroenterology, Imperial College London, London, UK.

出版信息

Frontline Gastroenterol. 2014 Jan;5(1):20-25. doi: 10.1136/flgastro-2013-100342. Epub 2013 Sep 3.

DOI:10.1136/flgastro-2013-100342
PMID:28839746
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5369711/
Abstract

OBJECTIVE

This pilot study was undertaken to assess the validity and effectiveness of near-patient coeliac immunological testing, compared to standard laboratory immunological techniques, used in the context of dietician-led coeliac disease follow-up clinics.

DESIGN

The study was designed in two phases, each assessing the near-patient test and standard laboratory immunological techniques. Phase 1 analysed stored serum samples; Phase 2 analysed whole blood from patients attending the dietician-led coeliac disease clinics.

SETTING

Patients were recruited from New Cross Hospital, Wolverhampton (n=50), and Imperial College London (n=30), between March 2010 and February 2011.

PATIENTS

Those with a diagnosis of coeliac disease for greater than 12 months attending dietician-led coeliac disease clinics.

INTERVENTIONS

In addition to whole blood taken for routine analysis, patients required a capillary finger-prick blood sample.

MAIN OUTCOME MEASURE

To determine if the whole blood and serum near-patient test results were in correlation with outcomes of standard laboratory evaluation.

RESULTS

Phase 1 demonstrated that the near-patient serum test had a sensitivity of 93.5% (95% CI 0.79% to 0.98%), specificity of 94.9% (0.83% to 0.99%), when compared to standard laboratory ELISA. Phase 2, involving patients whole blood, had a sensitivity of 77.8% (0.45% to 0.93%), and specificity of 100% (0.94% to 1%).

CONCLUSIONS

This pilot study has demonstrated that there appears to be a role for near-patient testing in coeliac disease, but further studies are recommended.

摘要

目的

开展这项初步研究，以评估在营养师主导的乳糜泻随访诊所中，与标准实验室免疫技术相比，即时检验乳糜泻免疫检测的有效性和准确性。

设计

该研究分两个阶段进行，每个阶段均对即时检验和标准实验室免疫技术进行评估。第一阶段分析储存的血清样本；第二阶段分析在营养师主导的乳糜泻诊所就诊患者的全血。

地点

2010年3月至2011年2月期间，从伍尔弗汉普顿的新十字医院（n = 50）和伦敦帝国学院（n = 30）招募患者。

患者

确诊乳糜泻超过12个月且在营养师主导的乳糜泻诊所就诊的患者。

干预措施

除采集用于常规分析的全血外，患者还需采集毛细血管指尖血样本。

主要观察指标

确定全血和血清即时检验结果是否与标准实验室评估结果相关。

结果

第一阶段表明，与标准实验室酶联免疫吸附测定（ELISA）相比，即时检验血清检测的灵敏度为93.5%（95%置信区间为0.79%至0.98%），特异性为94.9%（0.83%至0.99%）。第二阶段涉及患者全血，灵敏度为77.8%（0.45%至0.93%），特异性为100%（0.94%至1%）。

结论

这项初步研究表明，即时检验在乳糜泻检测中似乎有一定作用，但建议进一步开展研究。