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光学环形谐振器:用于生物传感应用的平台。

Optical Ring Resonators: A Platform for Biological Sensing Applications.

作者信息

Sarkaleh Azadeh Kiani, Lahijani Babak Vosoughi, Saberkari Hamidreza, Esmaeeli Ali

机构信息

Department of Electrical Engineering, Rasht Branch, Islamic Azad University, Rasht, Iran.

Department of Electrical Engineering, Sahand University of Technology, Tabriz, Iran.

出版信息

J Med Signals Sens. 2017 Jul-Sep;7(3):185-191.

Abstract

Rapid advances in biochemistry and genetics lead to expansion of the various medical instruments for detection and prevention tasks. On the other hand, food safety is an important concern which relates to the public health. One of the most reliable tools to detect bioparticles (., DNA molecules and proteins) and determining the authenticity of food products is the optical ring resonators. By depositing a recipient polymeric layer of target particle on the periphery of an optical ring resonator, it is possible to identify the existence of molecules by calculating the shift in the spectral response of the ring resonators. The main purpose of this paper is to investigate the performance of two structures of optical ring resonators, (i) all-pass and (ii) add-drop resonators for sensing applications. We propose a new configuration for sensing applications by introducing a nanogap in the all-pass ring resonator. The performance of these resonators is studied from sensing point of view. Simulation results, using finite difference time domain paradigm, revealed that the existence of a nanogap in the ring configuration achieves higher amount of sensitivity; thus, this structure is more suitable for biosensing applications.

摘要

生物化学和遗传学的快速发展促使各种用于检测和预防任务的医疗仪器不断扩充。另一方面,食品安全是关乎公众健康的重要问题。检测生物粒子(如DNA分子和蛋白质)以及确定食品真伪的最可靠工具之一是光学环形谐振器。通过在光学环形谐振器的周边沉积一层目标粒子的受体聚合物层,就有可能通过计算环形谐振器光谱响应的偏移来识别分子的存在。本文的主要目的是研究两种光学环形谐振器结构(即全通谐振器和分插复用谐振器)在传感应用中的性能。我们通过在全通环形谐振器中引入纳米间隙,提出了一种用于传感应用的新配置。从传感角度对这些谐振器的性能进行了研究。使用时域有限差分法的仿真结果表明,环形结构中纳米间隙的存在实现了更高的灵敏度;因此,这种结构更适合生物传感应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e7f/5551303/4260d03e9303/JMSS-7-185-g001.jpg

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