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自体干细胞联合核心减压治疗股骨头缺血性坏死：系统荟萃分析。

Autologous Stem Cells Combined Core Decompression for Treatment of Avascular Necrosis of the Femoral Head: A Systematic Meta-Analysis.

机构信息

The First Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China.

Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China.

出版信息

Biomed Res Int. 2017;2017:6136205. doi: 10.1155/2017/6136205. Epub 2017 Aug 3.

DOI:10.1155/2017/6136205
PMID:28840126
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5559921/
Abstract

OBJECTIVE

This study aims to systematically evaluate the efficacy and safety of core decompression combined transplantation of autologous bone marrow stem cells (CDBMSCs) for treatment of avascular necrosis of the femoral head (ANFH).

METHODS

Randomized controlled trials (RCTs) regarding effectiveness of core decompression combined transplantation of autologous bone marrow stem cells for treating ANFH were searched in 8 comprehensive databases prior to September 2016. The data analysis was performed by using the RevMan version 5.3.

RESULTS

A total of 11 studies with 507 participants were included. Results showed that CDBMSCs group was more effective than CD group in increasing Harris hip score, decreasing necrotic area of femoral head, collapse of femoral head, and conversion to total hip replacement incidence. In the subgroup analysis, the results did not change in different intervention measure substantially. In addition, the safety of CDBMSCs for ANFH is reliable.

CONCLUSION

Based on the systematic review, our findings suggest that core decompression combined transplantation of autologous bone marrow stem cells appeared to be more efficacious in the treatment at early stages of ANFH.

摘要

目的

本研究旨在系统评估核心减压联合自体骨髓干细胞移植（CDBMSCs）治疗股骨头坏死（ANFH）的疗效和安全性。

方法

检索 2016 年 9 月前 8 个综合数据库中有关核心减压联合自体骨髓干细胞移植治疗 ANFH 的有效性的随机对照试验（RCT）。使用 RevMan 版本 5.3 进行数据分析。

结果

共纳入 11 项研究，共计 507 名参与者。结果表明，CDBMSCs 组在增加 Harris 髋关节评分、减少股骨头坏死面积、股骨头塌陷和全髋关节置换发生率方面优于 CD 组。亚组分析显示，不同干预措施的结果没有实质性变化。此外，CDBMSCs 治疗 ANFH 的安全性可靠。

结论

基于系统评价，我们的研究结果表明，在治疗早期的 ANFH 时，核心减压联合自体骨髓干细胞移植似乎更有效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b9d/5559921/97972fdf6e3d/BMRI2017-6136205.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b9d/5559921/d3a9c39a9d2c/BMRI2017-6136205.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b9d/5559921/564ae4a76689/BMRI2017-6136205.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b9d/5559921/aedc2a372cce/BMRI2017-6136205.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b9d/5559921/f6fe4b66a358/BMRI2017-6136205.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b9d/5559921/041f43678cb8/BMRI2017-6136205.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b9d/5559921/97972fdf6e3d/BMRI2017-6136205.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b9d/5559921/d3a9c39a9d2c/BMRI2017-6136205.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b9d/5559921/564ae4a76689/BMRI2017-6136205.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b9d/5559921/aedc2a372cce/BMRI2017-6136205.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b9d/5559921/f6fe4b66a358/BMRI2017-6136205.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b9d/5559921/041f43678cb8/BMRI2017-6136205.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b9d/5559921/97972fdf6e3d/BMRI2017-6136205.006.jpg

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2
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Clinics (Sao Paulo). 2016 Feb;71(2):110-3. doi: 10.6061/clinics/2016(02)10.
3
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5
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