中国绝经后女性血清维生素D与颈动脉内膜中层厚度的负相关关系。
Inverse association of serum vitamin D in relation to carotid intima-media thickness in Chinese postmenopausal women.
作者信息
Hao Yaping, Ma Xiaojing, Luo Yuqi, Xu Yiting, Xiong Qin, Zhu Jiaan, Bao Yuqian, Jia Weiping
机构信息
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital; Shanghai Clinical Center for Diabetes; Shanghai Key Clinical Center for Metabolic Disease; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China.
Department of Ultrasound, Shanghai Jiao Tong University Affiliated Sixth People's Hospital; Shanghai Institute of Ultrasound in Medicine, Shanghai 200233, China.
出版信息
PLoS One. 2015 Mar 30;10(3):e0122803. doi: 10.1371/journal.pone.0122803. eCollection 2015.
OBJECTIVE
This study aimed to investigate the relationship between serum vitamin D level and carotid intima-media thickness (C-IMT) in Chinese postmenopausal women.
METHODS
Nine hundred and twenty six Chinese postmenopausal women without carotid artery plaque or history of cardiovascular disease were selected for analysis. Measurements of serum 25 hydroxyvitamin D3 (25(OH)D3) concentration and C-IMT were made by electrochemiluminescence immunoassay and B-mode ultrasound, respectively. Trend analysis was conducted according to tertiles of C-IMT.
RESULTS
The median serum 25(OH)D3 level was 11.03 ng/mL, with an interquartile range of 8.22-14.70. A decreasing trend of serum 25(OH)D3 level was accompanied by increased C-IMT tertiles (P for trend = 0.001). Correlation analysis found an inverse relationship between serum 25(OH)D3 level and C-IMT (r = -0.113, P = 0.001). After adjustment for confounding factors, multiple regression analysis showed that serum 25(OH)D3 level independently and negatively associated with C-IMT (Standard β = -0.112, P < 0.001). Moreover, the inverse correlation of serum 25(OH)D3 with C-IMT was also found in a subgroup of women with normal glucose tolerance, blood pressure and body mass index, and without undergoing lipid-lowering therapy (standard β = -0.140, P = 0.018).
CONCLUSIONS
Serum 25(OH)D3 level was inversely correlated with C-IMT in Chinese postmenopausal women.
目的
本研究旨在探讨中国绝经后女性血清维生素D水平与颈动脉内膜中层厚度（C-IMT）之间的关系。
方法
选取926例无颈动脉斑块或心血管疾病史的中国绝经后女性进行分析。分别采用电化学发光免疫分析法和B型超声测量血清25羟维生素D3（25(OH)D3）浓度和C-IMT。根据C-IMT三分位数进行趋势分析。
结果
血清25(OH)D3水平中位数为11.03 ng/mL，四分位间距为8.22 - 14.70。血清25(OH)D3水平呈下降趋势，同时C-IMT三分位数增加（趋势P = 0.001）。相关性分析发现血清25(OH)D3水平与C-IMT呈负相关（r = -0.113，P = 0.001）。校正混杂因素后，多元回归分析显示血清25(OH)D3水平独立且与C-IMT呈负相关（标准β = -0.112，P < 0.001）。此外，在糖耐量、血压和体重指数正常且未接受降脂治疗的女性亚组中也发现血清25(OH)D3与C-IMT呈负相关（标准β = -0.140，P = 0.018）。
结论
中国绝经后女性血清25(OH)D3水平与C-IMT呈负相关。
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