Sarikaya Bayram Özlem, Latgé Jean Paul, Bayram Özgür
Biology Department, Maynooth University, Maynooth, Co. Kildare, Ireland.
Unité des Aspergillus, Institut Pasteur, 75015, Paris, France.
Curr Genet. 2018 Feb;64(1):141-146. doi: 10.1007/s00294-017-0740-5. Epub 2017 Aug 24.
Aspergillus fumigatus is an opportunistic human pathogen that causes various complications in patients with a weakened immune system functions. Asexual spores of A. fumigatus are responsible for initiation of aspergillosis. Long-term viability and proper germination of dormant conidia depend on trehalose accumulation, which protect the spores against thermal and oxidative stress. A putative Myb transcription factor, MybA has been recently found to be responsible for a variety of physiological and molecular roles ranging from conidiation, spore viability, trehalose accumulation, cell wall integrity and protection against reactive oxygen species. In this perspective review, we discuss the recent findings of MybA and its overlapping functions with the other regulators of conidia viability and trehalose accumulation. Therefore, the aim of this perspective is to raise interesting and stimulating questions on the molecular functions of MybA in conidiation and trehalose biogenesis and to question its genetic and physical interactions with the other regulators of conidial viability.
烟曲霉是一种机会性人类病原体，可在免疫系统功能减弱的患者中引发各种并发症。烟曲霉的无性孢子是曲霉病发病的原因。休眠分生孢子的长期活力和正常萌发依赖于海藻糖的积累，海藻糖可保护孢子免受热应激和氧化应激。最近发现一种假定的Myb转录因子MybA负责多种生理和分子功能，范围从分生孢子形成、孢子活力、海藻糖积累、细胞壁完整性以及对活性氧的保护。在这篇观点综述中，我们讨论了MybA的最新发现及其与分生孢子活力和海藻糖积累的其他调节因子的重叠功能。因此，本观点的目的是就MybA在分生孢子形成和海藻糖生物合成中的分子功能提出有趣且具有启发性的问题，并质疑其与分生孢子活力的其他调节因子的遗传和物理相互作用。
