College of Medicine, Pennsylvania State University, Hershey, PA, USA.
University of Pennsylvania, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Support Care Cancer. 2018 Feb;26(2):507-514. doi: 10.1007/s00520-017-3856-8. Epub 2017 Aug 24.
Exercise is recommended following cancer diagnosis and may be particularly valuable for women receiving cardiotoxic chemotherapy treatments. We investigated breast cancer patient preference on exercise programming in a prospective manner and retrospectively assessed length of time between diagnosis and chemotherapy initiation. Sixty-seven newly diagnosed breast cancer patients responded to questions regarding exercise programming related to cancer treatment and surveys on current activity level. Additionally, a retrospective chart review was conducted on 500 random breast cancer patients. Age, cancer stage, treatment, and treatment dates were extracted. Women were interested in, or, absolutely wanted to, participate in an exercise program before treatment (76.2%). There was uncertainty regarding willingness to delay treatment; 49.2% were willing to delay their treatment if the program was recommended by their doctors, 41.8% would not, and 9.0% were too unsure to respond. However, women would like to hear information about an exercise program for cancer patients when they are first diagnosed (61.9%). We observed that 64.6% of women were below recommended levels of physical activity; yet, current activity was not associated with an interest in an exercise program or willingness to delay treatment. Retrospectively, we observed an average interval of 72.6 ± 34.6 days between cancer diagnosis and initiation of anthracycline-based chemotherapy treatment, with younger women with more advanced cancer receiving anthracycline-based chemotherapy. Based on patient preference and length of time to chemotherapy initiation, a reasonable next step to promote the current recommendations for exercise could be to integrate exercise into breast cancer care earlier in treatment.
运动被推荐用于癌症诊断后，对于接受心脏毒性化疗治疗的女性可能特别有价值。我们前瞻性地调查了乳腺癌患者对运动方案的偏好，并回顾性评估了诊断与化疗开始之间的时间长短。67 名新诊断的乳腺癌患者对与癌症治疗相关的运动方案问题做出了回应，并对当前活动水平进行了调查。此外，对 500 名随机乳腺癌患者进行了回顾性图表审查。提取了年龄、癌症分期、治疗和治疗日期。女性对治疗前的运动项目感兴趣，或绝对想参加（76.2%）。她们对推迟治疗的意愿存在不确定性；如果医生推荐该方案，49.2%的女性愿意推迟治疗，41.8%的女性不愿意，9.0%的女性则不确定是否会推迟。然而，女性希望在初次诊断时就听到有关癌症患者运动方案的信息（61.9%）。我们观察到 64.6%的女性体力活动水平低于推荐水平；然而，当前的活动水平与对运动方案的兴趣或推迟治疗的意愿无关。回顾性观察到，从癌症诊断到开始蒽环类药物化疗治疗的平均间隔时间为 72.6±34.6 天，年轻、癌症分期更晚的女性接受蒽环类药物化疗治疗。基于患者的偏好和开始化疗的时间，促进目前运动建议的下一步合理措施可能是在治疗早期将运动纳入乳腺癌护理中。
