Zhang Heng, Liu Mingbin, Zeng Xiaoxu, Zhao Xiang, Deng Zhiqiang, Yang Lei, Chen Wenbing, Li Zi, Jiao Ming, Xia Wen, Han Bin, Chen Haiying, Shu Yuelong, Wang Dayan
Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, 102206, People's Republic of China.
Nanchang Center for Disease Control and Prevention, Nanchang, 330038, People's Republic of China.
Arch Virol. 2017 Dec;162(12):3681-3690. doi: 10.1007/s00705-017-3507-x. Epub 2017 Aug 24.
Live poultry markets (LPM) are one of the most important sources of human infection with avian influenza virus (AIV). During our routine surveillance of AIV, we identified an H9N6 virus (JX-H9N6) in a LPM in Nanchang city, Jiangxi Province, China. Using Bayesian coalescent analysis, it was predicted that JX-H9N6 had originated from a reassortment event between H9N2 and H6N6 AIVs in early 2014, instead of being derived from an H9N6 virus reported previously. Mutations in HA, PB1, PA, M, and NS protein, which could increase mammalian transmission and virulence, were also detected. Currently, both H9N2 and H6N6 AIVs are widely distributed in poultry and contribute to the generation of novel reassortant viruses causing human infection. Our findings highlight the importance of enhanced surveillance in birds for early prediction of human infections.
活禽市场是人类感染禽流感病毒（AIV）的最重要来源之一。在我们对禽流感病毒的常规监测过程中，我们在中国江西省南昌市的一个活禽市场中鉴定出一株H9N6病毒（JX-H9N6）。使用贝叶斯合并分析预测，JX-H9N6起源于2014年初H9N2和H6N6禽流感病毒之间的重配事件，而非源自先前报道的H9N6病毒。还检测到血凝素（HA）、聚合酶基本蛋白1（PB1）、聚合酶酸性蛋白（PA）、基质蛋白（M）和非结构蛋白（NS）中的突变，这些突变可能增加病毒在哺乳动物中的传播和毒力。目前，H9N2和H6N6禽流感病毒均在禽类中广泛分布，并促使新型重配病毒的产生，从而导致人类感染。我们的研究结果凸显了加强鸟类监测以早期预测人类感染的重要性。
