Diamond L E, Berman J W, Pellicer A
Cell Immunol. 1987 Jun;107(1):115-20. doi: 10.1016/0008-8749(87)90271-1.
Expression of several thymocyte surface antigens was monitored in a murine model system of thymic lymphoma induction in two different strains of mice. RF/J mice are sensitive to tumor induction by N-nitrosomethylurea (NMU) and by gamma-irradiation, while 129/J mice form tumors only upon NMU treatment. Latency periods for tumor formation were characteristically different depending upon the inducing agent and the mouse strain. We observed differences in thymic leukemia antigen and H-2K expression according to the mode of tumor induction and in relation to the mouse strain, implying multiple factors involved in target cell selection and tumor progression.
在两种不同品系小鼠的胸腺淋巴瘤诱导小鼠模型系统中，监测了几种胸腺细胞表面抗原的表达。RF/J小鼠对N-亚硝基甲基脲（NMU）和γ射线诱导肿瘤敏感，而129/J小鼠仅在接受NMU处理后才形成肿瘤。根据诱导剂和小鼠品系的不同，肿瘤形成的潜伏期有显著差异。我们观察到，根据肿瘤诱导方式以及与小鼠品系的关系，胸腺白血病抗原和H-2K表达存在差异，这意味着在靶细胞选择和肿瘤进展过程中有多种因素参与。
