Friedman Matthew J, Huber Bertrand R, Brady Christopher B, Ursano Robert J, Benedek David M, Kowall Neil W, McKee Ann C
National Center for PTSD, VA Medical Center, U.S. Department of Veterans Affairs, 215 North Main Street, White River Junction, VT, 05009, USA.
Department of Psychiatry, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
Curr Psychiatry Rep. 2017 Aug 25;19(10):73. doi: 10.1007/s11920-017-0822-6.
The National PTSD Brain Bank (NPBB) is a brain tissue biorepository established to support research on the causes, progression, and treatment of PTSD. It is a six-part consortium led by VA's National Center for PTSD with participating sites at VA medical centers in Boston, MA; Durham, NC; Miami, FL; West Haven, CT; and White River Junction, VT along with the Uniformed Services University of Health Sciences. It is also well integrated with VA's Boston-based brain banks that focus on Alzheimer's disease, ALS, chronic traumatic encephalopathy, and other neurological disorders. This article describes the organization and operations of NPBB with specific attention to: tissue acquisition, tissue processing, diagnostic assessment, maintenance of a confidential data biorepository, adherence to ethical standards, governance, accomplishments to date, and future challenges. Established in 2014, NPBB has already acquired and distributed brain tissue to support research on how PTSD affects brain structure and function.
国家创伤后应激障碍脑库（NPBB）是一个脑组织生物样本库，旨在支持对创伤后应激障碍的病因、进展和治疗的研究。它是一个由美国退伍军人事务部国家创伤后应激障碍中心牵头的六方联盟，参与地点包括马萨诸塞州波士顿、北卡罗来纳州达勒姆、佛罗里达州迈阿密、康涅狄格州韦斯特黑文、佛蒙特州怀特河 Junction 的退伍军人事务部医疗中心以及美国军医大学。它还与退伍军人事务部位于波士顿的专注于阿尔茨海默病、肌萎缩侧索硬化症、慢性创伤性脑病和其他神经疾病的脑库紧密整合。本文介绍了 NPBB 的组织架构和运作情况，特别关注：组织采集、组织处理、诊断评估、保密数据生物样本库的维护、遵守道德标准、治理、迄今取得的成就以及未来的挑战。NPBB 成立于 2014 年，已经获取并分发脑组织以支持关于创伤后应激障碍如何影响脑结构和功能的研究。
