Ravid Rivka, Ikemoto Keiko
Netherlands Institute of Neurosciences, Meibergdreef 47, Amsterdam, The Netherlands.
Fukushima J Med Sci. 2012;58(1):82-7. doi: 10.5387/fms.58.82.
It is essential to examine brain materials for the understanding the cause and pathology of mental disorders. Recent methodological progress urges us to set up well qualified brain banks. Human tissue and Bio-banking is a complex field and the daily practice of brain banks needs to abide by several golden standards in order to avoid pitfalls in basic research: 1) A donor system in which informed consent is granted for the use of the samples for scientific research, including genetic analysis and access to medical records, 2) Rapid autopsy system, 3) Compatibility of protocols for procurement, management, handling and storage, 4) A generally accepted consensus on diagnostic criteria, 5) Quality control, 6) Abiding by local/international legal and ethical guidelines for work with human material, 7) Proper safety procedures. In the present review, the authors introduced the activities of European brain banks, and discussed on their current issues, and on the problems remain to be resolved.
为了理解精神障碍的病因和病理，检查脑材料至关重要。最近的方法学进展促使我们建立资质良好的脑库。人体组织和生物样本库是一个复杂的领域，脑库的日常运作需要遵循若干黄金标准，以避免基础研究中的陷阱：1）一个捐赠者系统，其中捐赠者同意将样本用于科学研究，包括基因分析和获取医疗记录；2）快速尸检系统；3）采购、管理、处理和存储协议的兼容性；4）对诊断标准达成普遍接受的共识；5）质量控制；6）遵守与人体材料相关的当地/国际法律和道德准则；7）适当的安全程序。在本综述中，作者介绍了欧洲脑库的活动，并讨论了它们当前的问题以及有待解决的问题。
