Ma Xiaoyu, Sun Xiangcheng, Chen Jun, Lei Yu
Department of Biomedical Engineering, University of Connecticut, Storrs, CT, 06269, USA.
Department of Chemistry, Cornell University, Ithaca, NY, 14850, USA.
Appl Biochem Biotechnol. 2017 Oct;183(2):461-487. doi: 10.1007/s12010-017-2570-9. Epub 2017 Aug 24.
Fluorescent polymeric materials such as hydrogels and particles have been attracting attention in many biomedical applications including bio-imaging, optical sensing, tissue engineering, due to their good biocompatibility, biodegradability, and advanced optical property. This review article aims at summarizing recent progress in fluorescent hydrogels and particles based on natural polymers or natural-synthetic hybrid polymers as the building blocks with a concentration on their bio-imaging-related applications. The challenges and future perspectives for the development of natural or natural-synthetic hybrid polymer-based fluorescent hydrogels and particles are also presented.
诸如水凝胶和颗粒等荧光聚合物材料,因其良好的生物相容性、生物降解性和先进的光学特性,在包括生物成像、光学传感、组织工程在内的许多生物医学应用中一直备受关注。这篇综述文章旨在总结以天然聚合物或天然-合成杂化聚合物为构建单元的荧光水凝胶和颗粒的最新进展,重点关注其与生物成像相关的应用。同时还介绍了基于天然或天然-合成杂化聚合物的荧光水凝胶和颗粒开发所面临的挑战和未来前景。