Department of Materials Science and Engineering, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama-cho, Toyonaka, Osaka, Japan.
Chem Asian J. 2017 Dec 14;12(24):3098-3109. doi: 10.1002/asia.201701364. Epub 2017 Nov 23.
Horseradish peroxidase (HRP)-catalyzed hydrogelation has attracted much attention owing to the ease of handling, high biocompatibility, and processability. This review summarizes recent developments, including cutting-edge research into the use of HRP-mediated hydrogelation toward biomedical, biopharmaceutical, and biofabrication applications. From the viewpoint of polymer chemistry, the basic chemistry behind hydrogelation, the structure-property relationship, and hybridization of multiple materials by using HRP-catalyzed hydrogelation are summarized. From the chemical engineering perspective, strategies for controlling hydrogelation kinetics, hydrogel characteristics, and hydrogelation processes are summarized and discussed in detail. Strategies for obtaining biomaterials for medical and pharmaceutical use, and biofabrication for tissue engineering and regenerative medicine emerge by unifying the aspects of HRP-mediated hydrogelation.
辣根过氧化物酶（HRP）催化的水凝胶化由于其易于处理、高生物相容性和可加工性而受到广泛关注。本综述总结了最近的发展，包括使用 HRP 介导的水凝胶化在生物医学、生物制药和生物制造应用方面的前沿研究。从聚合物化学的角度来看，总结了水凝胶化背后的基本化学、结构-性质关系以及通过 HRP 催化的水凝胶化对多种材料的杂化。从化学工程的角度来看，详细总结和讨论了控制水凝胶化动力学、水凝胶特性和水凝胶化过程的策略。通过统一 HRP 介导的水凝胶化的各个方面，出现了用于医疗和药物用途的生物材料以及组织工程和再生医学的生物制造的策略。
