Szabó Eszter, Kósa Csaba, Babarczi Edit, Sulyok Mihály, Ujhelyi Eszter, Bánhegyi Dénes, Vályi-Nagy István
Molecular Biology Laboratory, St. István and St. László Hospital, Albert Flórián str. 5-7, Budapest, 1097, Hungary.
Institute of Biology Department of Immunology, Eötvös Loránd University, Pázmány Péter str. 1/c, Budapest, 1117, Hungary.
Pathol Oncol Res. 2018 Jul;24(3):671-677. doi: 10.1007/s12253-017-0292-5. Epub 2017 Aug 24.
Anal cancer is one of the leading causes of death in non-AIDS defining cancers. Most of these cancers are associated with high risk HPV infection. So far, the prevalence and the significance of anal HPV infection have not been studied in the Hungarian MSM population. The main objective of our study was to determine the prevalence and associated risk factors of HPV-infection in the Hungarian MSM community, particularly in HIV-infected MSM. Out of 109 examinations 92 samples (80 HIV-infected and 12 HIV-negative MSM) were evaluated for both cytological abnormalities and HPV genotyping PCR. Using a questionnaire all enrolled individuals were interviewed about their sexual behavior, socioeconomic factors, drug use and other known or suspected risk factors. In the HIV-infected cohort 97.5% of the examined individuals were positive for any HPV type. In this group we detected high risk (HR) HPV in 88.8%, low risk (LR) HPV in 75.0% and probably high risk (PHR) HPV in 47.5% and multiple HPV infection was absolutely common (82.5%). In the HIV-negative MSM group the incidence of HPV-infection was 58.3%. The respective rate of HR-HPV, LR-HPV and PHR-HPV genotypes were 33.3%, 58.4%, and 16.7%. In the HIV-negative group both HPV infection frequency and the prevalence of the pertinent genotypes were much lower. The Hungarian MSM population is severely infected with HPV and HR-HPV. High-risk sexual behaviors are strong predictors for acquiring HR-HPV co-infections. Our results underline the necessity of anal cancer screening and the introduction of the vaccination program in the high-risk population.
肛门癌是非艾滋病定义癌症中主要的死亡原因之一。这些癌症大多与高危型人乳头瘤病毒（HPV）感染有关。到目前为止，匈牙利男男性行为者（MSM）人群中肛门HPV感染的患病率及其意义尚未得到研究。我们研究的主要目的是确定匈牙利MSM群体中HPV感染的患病率及其相关危险因素，特别是在感染HIV的MSM中。在109次检查中，对92份样本（80名感染HIV的MSM和12名未感染HIV的MSM）进行了细胞学异常和HPV基因分型PCR评估。通过问卷调查，对所有入组个体进行了关于其性行为、社会经济因素、药物使用及其他已知或疑似危险因素的访谈。在感染HIV的队列中，97.5%的受检个体任何HPV类型检测均为阳性。在该组中，我们检测到高危（HR）HPV的比例为88.8%，低危（LR）HPV为75.0%，可能高危（PHR）HPV为47.5%，多重HPV感染非常常见（82.5%）。在未感染HIV的MSM组中，HPV感染率为58.3%。HR-HPV、LR-HPV和PHR-HPV基因型的相应比例分别为33.3%、58.4%和16.7%。在未感染HIV的组中，HPV感染频率和相关基因型的患病率均低得多。匈牙利MSM人群严重感染HPV和HR-HPV。高危性行为是获得HR-HPV合并感染的有力预测因素。我们的结果强调了在高危人群中进行肛门癌筛查和引入疫苗接种计划的必要性。
