Department of Chemistry, Indian Institute of Technology Kanpur , Kanpur-208016, India.
Department of Chemistry, Visva Bharati University , Santiniketan, West Bengal 731235, India.
Org Lett. 2017 Sep 15;19(18):4750-4753. doi: 10.1021/acs.orglett.7b02105. Epub 2017 Aug 25.
Ru(II) catalyzed tandem synthesis of α-branched methylated ketones via multicomponent reactions following the hydrogen borrowing process is described. This nonphosphine-based air and moisture stable catalyst efficiently produced various methylated ketones using methanol as a methylating agent. This system was found to be highly effective in three-component coupling between methanol, primary alcohols, and methyl ketones. A proposed catalytic cycle for the α-methylation is supported by DFT calculations as well as kinetic experiments.
描述了 Ru(II) 催化的多组分反应通过氢借过程串联合成α-支链甲基化酮。这种非膦基的空气和水分稳定催化剂使用甲醇作为甲基化试剂有效地生成了各种甲基化酮。该体系在甲醇、伯醇和甲基酮的三组分偶联中表现出很高的活性。DFT 计算和动力学实验都支持了α-甲基化的催化循环。
